loading...| Preferred Name |
clotrimazole |
|
| Synonyms |
Lotrimin |
|
| Definitions |
A synthetic, imidazole derivate with broad-spectrum, antifungal activity. Clotrimazole inhibits biosynthesis of sterols, particularly ergosterol, an essential component of the fungal cell membrane, thereby damaging and affecting the permeability of the cell membrane. This results in leakage and loss of essential intracellular compounds, and eventually causes cell lysis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C381" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C381" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039116 |
|
| altLabel |
Lotrimin Mycelex Troche Mycelex Gyne-Lotrimin 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole CLOT |
|
| CAS Registry |
23593-75-1 |
|
| Component of | ||
| cui |
C0306874 C0699670 C0009074 C0720789 C0699671 |
|
| Date last modified |
2017-10-23 |
|
| definition |
A synthetic, imidazole derivate with broad-spectrum, antifungal activity. Clotrimazole inhibits biosynthesis of sterols, particularly ergosterol, an essential component of the fungal cell membrane, thereby damaging and affecting the permeability of the cell membrane. This results in leakage and loss of essential intracellular compounds, and eventually causes cell lysis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C381" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C381" NCI Thesaurus) |
|
| Legacy PDQ ID |
1706 |
|
| LT |
TRD |
|
| NCI ID |
C381 |
|
| notation |
CDR0000039116 |
|
| NSC Code |
257473 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
clotrimazole |
|
| tui |
T109 T121 |