Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

hydroxychloroquine

Synonyms

HCQ

Definitions

A 4-aminoquinoline with immunosuppressive, antiautophagy, and antimalarial activities. Although the precise mechanism of action is unknown, hydroxychloroquine may suppress immune function by interfering with the processing and presentation of antigens and the production of cytokines. As a lysosomotropic agent, hydroxychloroquine raises intralysosomal pH, impairing autophagic protein degradation; hydroxychloroquine-mediated accumulation of ineffective autophagosomes may result in cell death in tumor cells reliant on autophagy for survival. In addition, this agent is highly active against the erythrocytic forms of P. vivax and malariae and most strains of P. falciparum but not the gametocytes of P. falciparum. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C557" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C557" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000038571

altLabel

HCQ

CAS Registry

118-42-3

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000038572

http://purl.bioontology.org/ontology/PDQ/CDR0000038573

cui

C0020336

Date last modified

2008-07-17

definition

A 4-aminoquinoline with immunosuppressive, antiautophagy, and antimalarial activities. Although the precise mechanism of action is unknown, hydroxychloroquine may suppress immune function by interfering with the processing and presentation of antigens and the production of cytokines. As a lysosomotropic agent, hydroxychloroquine raises intralysosomal pH, impairing autophagic protein degradation; hydroxychloroquine-mediated accumulation of ineffective autophagosomes may result in cell death in tumor cells reliant on autophagy for survival. In addition, this agent is highly active against the erythrocytic forms of P. vivax and malariae and most strains of P. falciparum but not the gametocytes of P. falciparum. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C557" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C557" NCI Thesaurus)

Legacy PDQ ID

11201

NCI ID

C557

notation

CDR0000038571

ORIG STY

Drug/agent

prefLabel

hydroxychloroquine

tui

T109

T121

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/SNOMEDCT/83490000 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNMI/C-56520 SNMI CUI
http://purl.bioontology.org/ontology/MESH/D006886 MESH CUI
http://purl.bioontology.org/ontology/NDDF/004906 NDDF CUI
http://purl.bioontology.org/ontology/SNOMEDCT/373540008 SNOMEDCT CUI
http://purl.bioontology.org/ontology/ATC/P01BA02 ATC CUI
http://purl.bioontology.org/ontology/RCD/x01J9 RCD CUI
http://purl.bioontology.org/ontology/SCTSPA/373540008 SCTSPA CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147871 NDFRT CUI
http://purl.bioontology.org/ontology/LNC/MTHU016851 LOINC CUI
http://purl.bioontology.org/ontology/SCTSPA/83490000 SCTSPA CUI
http://purl.bioontology.org/ontology/MSHFRE/D006886 MSHFRE CUI
http://purl.bioontology.org/ontology/VANDF/4019780 VANDF CUI
http://purl.bioontology.org/ontology/LNC/LP16163-5 LOINC CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006573 NDFRT CUI
http://purl.bioontology.org/ontology/RXNORM/5521 RXNORM CUI
http://purl.bioontology.org/ontology/CSP/2530-4570 CRISP CUI
https://github.com/sap218/coid/blob/master/coid.owl#COID_00901 COID LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D006886 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-56520 SNMI LOOM
https://go.drugbank.com/drugs/DB01611 MDM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0020336 OCHV LOOM
https://github.com/sap218/coid/blob/master/coid.owl#COID_00466 COID LOOM
http://purl.bioontology.org/ontology/MESH/D006886 MESH LOOM
http://purl.bioontology.org/ontology/NDDF/004906 NDDF LOOM
http://www.drugbank.ca/drugs/DB01611 FTC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#6376 OCHV LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147871 INBANCIDO LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147871 CIDO LOOM
http://www.co-ode.org/ontologies/galen#Hydroxychloroquine GALEN LOOM
http://purl.obolibrary.org/obo/NCIT_C557 BERO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373540008 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/ATC/P01BA02 ATC LOOM
http://purl.bioontology.org/ontology/RCD/x01J9 RCD LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017887 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/CHEBI_5801 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_5801 EUPATH LOOM
http://purl.obolibrary.org/obo/CHEBI_5801 INBANCIDO LOOM
http://purl.obolibrary.org/obo/CHEBI_5801 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_5801 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_5801 COVID-19 LOOM
http://purl.obolibrary.org/obo/CHEBI_5801 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_5801 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_5801 CIDO LOOM
http://purl.obolibrary.org/obo/CHEBI_5801 CHEBI LOOM
http://stirdf.jst.go.jp/id/200907075625870984 IOBC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147871 NDFRT LOOM
http://purl.obolibrary.org/obo/DRON_00010111 INBANCIDO LOOM
http://purl.obolibrary.org/obo/DRON_00010111 CIDO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU016851 LOINC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C557 NCIT LOOM
http://purl.jp/bio/4/id/200906071760982882 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4019780 VANDF LOOM
http://purl.bioontology.org/ontology/LNC/LP16163-5 LOINC LOOM
http://bmi.utah.edu/ontologies/peontology/C0020336 RAO LOOM
http://purl.obolibrary.org/obo/OMIT_0008023 OMIT LOOM
http://purl.bioontology.org/ontology/RXNORM/5521 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.810.050.180.350 RH-MESH LOOM
http://purl.obolibrary.org/obo/MESH_D006886 BERO LOOM