Physician Data Query

Last uploaded: April 29, 2019
Preferred Name

rofecoxib

Synonyms

Vioxx

Definitions

A synthetic, nonsteroidal derivative of phenyl-furanone with antiinflammatory, antipyretic and analgesic properties and potential antineoplastic properties. Rofecoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. COX-related metabolic pathways may represent key regulators of cell proliferation and neo-angiogenesis. Some epithelial tumor cell types overexpress pro-angiogenic COX-2. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38568&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38568&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1832" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000038568

altLabel

Vioxx

MK 966

4-[4'-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone

CAS Registry

162011-90-7

cui

C0762662

C0766718

C0876768

Date last modified

2006-05-10

definition

A synthetic, nonsteroidal derivative of phenyl-furanone with antiinflammatory, antipyretic and analgesic properties and potential antineoplastic properties. Rofecoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. COX-related metabolic pathways may represent key regulators of cell proliferation and neo-angiogenesis. Some epithelial tumor cell types overexpress pro-angiogenic COX-2. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38568&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38568&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1832" NCI Thesaurus)

Legacy PDQ ID

11199

LT

TRD

NCI ID

C1832

notation

CDR0000038568

ORIG STY

Drug/agent

prefLabel

rofecoxib

tui

T109

T121

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http://purl.bioontology.org/ontology/NDFRT/N0000148611 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148611 NDFRT LOOM
http://purl.bioontology.org/ontology/LNC/LP171636-6 LOINC CUI
http://purl.bioontology.org/ontology/LNC/LP171636-6 LOINC LOOM
http://purl.obolibrary.org/obo/DRON_00015719 ODNAE LOOM
http://purl.obolibrary.org/obo/DRON_00015719 DRON LOOM
http://scai.fraunhofer.de/AlzheimerOntology#rofecoxib ADO LOOM
http://purl.bioontology.org/ontology/UATC/M01AH02 ATC CUI
http://purl.bioontology.org/ontology/UATC/M01AH02 ATC LOOM
http://purl.bioontology.org/ontology/RXNORM/262149 RXNORM CUI
http://doe-generated-ontology.com/OntoAD#C0762662 ONTOAD LOOM
http://purl.bioontology.org/ontology/CSP/5005-0005 CRISP CUI
http://purl.bioontology.org/ontology/CSP/5005-0005 CRISP CUI
http://purl.bioontology.org/ontology/RXNORM/232158 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/232158 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C116926 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/116095002 SNOMEDCT CUI
http://purl.bioontology.org/ontology/VANDF/4021160 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4021160 VANDF LOOM
http://purl.obolibrary.org/obo/CHEBI_8887 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_8887 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8887 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8887 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_8887 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8887 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_8887 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_8887 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_8887 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8887 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_8887 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_8887 EFO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1832 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1832 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1832 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1832 NCIT LOOM
http://purl.bioontology.org/ontology/MESH/C116926 MESH CUI
http://purl.bioontology.org/ontology/MESH/C116926 MESH CUI
http://purl.bioontology.org/ontology/MESH/C116926 MESH CUI
http://purl.bioontology.org/ontology/MESH/C116926 MESH LOOM
http://purl.bioontology.org/ontology/NDDF/007787 NDDF CUI
http://purl.bioontology.org/ontology/NDDF/007787 NDDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000006529 NDFRT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387008005 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387008005 SNOMEDCT LOOM
http://www.co-ode.org/ontologies/galen#Rofecoxib GALEN LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148611 ODAE LOOM
http://www.drugbank.ca/drugs/DB00533 FTC LOOM
http://bmi.utah.edu/ontologies/hfontology/C0762662 HFO LOOM