loading...| Preferred Name |
imiquimod |
|
| Synonyms |
4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline |
|
| Definitions |
A synthetic agent with immune response modifying activity. As an immune response modifier (IRM), imiquimod stimulates cytokine production, especially interferon production, and exhibits antitumor activity, particularly against cutaneous cancers. Imiquimod's proapoptotic activity appears to be related to Bcl-2 overexpression in susceptible tumor cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1431" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1431" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000038558 |
|
| altLabel |
4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline R 837 1H-Imidazo(4,5-c)quinolin-4-amine, 1-(2-methylpropyl)- IMQ Aldara S 26308 |
|
| CAS Registry |
99011-02-6 |
|
| Component of | ||
| cui |
C0165032 C0718327 C0139801 C0073766 |
|
| Date last modified |
2006-08-27 |
|
| definition |
A synthetic agent with immune response modifying activity. As an immune response modifier (IRM), imiquimod stimulates cytokine production, especially interferon production, and exhibits antitumor activity, particularly against cutaneous cancers. Imiquimod's proapoptotic activity appears to be related to Bcl-2 overexpression in susceptible tumor cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1431" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1431" NCI Thesaurus) |
|
| Legacy PDQ ID |
11189 |
|
| LT |
TRD |
|
| NCI ID |
C1431 |
|
| notation |
CDR0000038558 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
imiquimod |
|
| tui |
T109 T121 |