Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

ipilimumab

Synonyms

monoclonal antibody CTLA-4

Definitions

A recombinant human immunoglobulin (Ig) G1 monoclonal antibody directed against the human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4), with immune checkpoint inhibitory and antineoplastic activities. Ipilimumab binds to CTLA4 expressed on T-cells and inhibits the CTLA4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA4, an inhibitory receptor and member of the immunoglobulin superfamily, plays a key role in the downregulation of the immune system. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2654" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2654" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000038447

altLabel

monoclonal antibody CTLA-4

MOAB CTLA-4

Yervoy

MDX-CTLA4

BMS-734016

anti-cytotoxic T-lymphocyte-associated antigen-4 monoclonal antibody

MDX-010

MDX-CTLA-4

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000441036

http://purl.bioontology.org/ontology/PDQ/CDR0000385552

http://purl.bioontology.org/ontology/PDQ/CDR0000355803

http://purl.bioontology.org/ontology/PDQ/CDR0000038448

http://purl.bioontology.org/ontology/PDQ/CDR0000409698

http://purl.bioontology.org/ontology/PDQ/CDR0000315587

http://purl.bioontology.org/ontology/PDQ/CDR0000299437

http://purl.bioontology.org/ontology/PDQ/CDR0000038559

cui

C1692339

C1691227

C3853763

C3154308

C1367202

Date last modified

2015-07-10

definition

A recombinant human immunoglobulin (Ig) G1 monoclonal antibody directed against the human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4), with immune checkpoint inhibitory and antineoplastic activities. Ipilimumab binds to CTLA4 expressed on T-cells and inhibits the CTLA4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA4, an inhibitory receptor and member of the immunoglobulin superfamily, plays a key role in the downregulation of the immune system. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2654" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2654" NCI Thesaurus)

IND Code

10200

Legacy PDQ ID

11063

LT

TRD

NCI ID

C2654

notation

CDR0000038447

NSC Code

720801

ORIG STY

Drug/agent

prefLabel

ipilimumab

tui

T116

T129

T121

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/MESH/D000074324 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000074324 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000074324 MESH CUI
http://purl.bioontology.org/ontology/NDDF/013688 NDDF CUI
http://purl.bioontology.org/ontology/MSHFRE/D000074324 MSHFRE CUI
http://purl.bioontology.org/ontology/MSHFRE/D000074324 MSHFRE CUI
http://purl.bioontology.org/ontology/RXNORM/1094837 RXNORM CUI
http://purl.bioontology.org/ontology/MSHFRE/D000074324 MSHFRE CUI
http://purl.bioontology.org/ontology/SCTSPA/704649006 SCTSPA CUI
http://purl.bioontology.org/ontology/SNOMEDCT/704649006 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MESH/D000074324 MESH CUI
http://purl.bioontology.org/ontology/RXNORM/1094833 RXNORM CUI
http://purl.bioontology.org/ontology/SCTSPA/697995005 SCTSPA CUI
http://purl.bioontology.org/ontology/MSHFRE/D000074324 MSHFRE CUI
http://purl.bioontology.org/ontology/SNOMEDCT/697995005 SNOMEDCT CUI
http://purl.bioontology.org/ontology/ATC/L01FX04 ATC CUI
http://purl.bioontology.org/ontology/VANDF/4030653 VANDF CUI
http://purl.bioontology.org/ontology/NDFRT/N0000182641 NDFRT CUI
http://purl.bioontology.org/ontology/NDDF/013688 NDDF LOOM
https://go.drugbank.com/drugs/DB06186 MDM LOOM
http://purl.bioontology.org/ontology/MESH/D000074324 MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/1094833 RXNORM LOOM
http://purl.jp/bio/4/id/201306028792112642 IOBC LOOM
http://purl.obolibrary.org/obo/DRON_00020050 PDRO LOOM
http://purl.obolibrary.org/obo/DRON_00020050 DRON LOOM
http://purl.obolibrary.org/obo/DRON_00020050 ODNAE LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000182641 ODAE LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/697995005 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/ATC/L01FX04 ATC LOOM
http://purl.bioontology.org/ontology/VANDF/4030653 VANDF LOOM
http://purl.obolibrary.org/obo/NCIT_C2654 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C508317 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000182641 NDFRT LOOM
http://www.phoc.org.cn/pmo/class/PMO_00022047 PMAPP-PMO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2654 NCIT LOOM