Preferred Name |
ipilimumab |
|
Synonyms |
monoclonal antibody CTLA-4 |
|
Definitions |
A recombinant human immunoglobulin (Ig) G1 monoclonal antibody directed against the human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4), with immune checkpoint inhibitory and antineoplastic activities. Ipilimumab binds to CTLA4 expressed on T-cells and inhibits the CTLA4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA4, an inhibitory receptor and member of the immunoglobulin superfamily, plays a key role in the downregulation of the immune system. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2654" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2654" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000038447 |
|
altLabel |
monoclonal antibody CTLA-4 MOAB CTLA-4 Yervoy MDX-CTLA4 BMS-734016 anti-cytotoxic T-lymphocyte-associated antigen-4 monoclonal antibody MDX-010 MDX-CTLA-4 |
|
Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000441036 http://purl.bioontology.org/ontology/PDQ/CDR0000385552 http://purl.bioontology.org/ontology/PDQ/CDR0000355803 http://purl.bioontology.org/ontology/PDQ/CDR0000038448 http://purl.bioontology.org/ontology/PDQ/CDR0000409698 http://purl.bioontology.org/ontology/PDQ/CDR0000315587 |
|
cui |
C1692339 C1691227 C3853763 C3154308 C1367202 |
|
Date last modified |
2015-07-10 |
|
definition |
A recombinant human immunoglobulin (Ig) G1 monoclonal antibody directed against the human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4), with immune checkpoint inhibitory and antineoplastic activities. Ipilimumab binds to CTLA4 expressed on T-cells and inhibits the CTLA4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA4, an inhibitory receptor and member of the immunoglobulin superfamily, plays a key role in the downregulation of the immune system. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2654" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2654" NCI Thesaurus) |
|
IND Code |
10200 |
|
Legacy PDQ ID |
11063 |
|
LT |
TRD |
|
NCI ID |
C2654 |
|
notation |
CDR0000038447 |
|
NSC Code |
720801 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
ipilimumab |
|
tui |
T116 T129 T121 |