Physician Data Query

Last uploaded: July 6, 2018
Preferred Name

cefepime hydrochloride

Synonyms

cefepime

Definitions

The hydrochoride salt of a semi-synthetic, beta-lactamase-resistant, fourth-generation cephalosporin antibiotic derived from an Acremonium fungal species with broad-spectrum bactericidal activity. Administered parenterally, cefipime inhibits bacterial cell wall synthesis by binding to and inactivating penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, resulting in a reduction of bacterial cell wall stability and cell lysis. This agent is more active against a variety of Gram-positive pathogens compared to third-generation cephalosporins. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38350&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38350&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1041" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000038350

altLabel

cefepime

Maxipime

cui

C0771284

C0055003

C0284915

Date last modified

2006-07-06

definition

The hydrochoride salt of a semi-synthetic, beta-lactamase-resistant, fourth-generation cephalosporin antibiotic derived from an Acremonium fungal species with broad-spectrum bactericidal activity. Administered parenterally, cefipime inhibits bacterial cell wall synthesis by binding to and inactivating penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, resulting in a reduction of bacterial cell wall stability and cell lysis. This agent is more active against a variety of Gram-positive pathogens compared to third-generation cephalosporins. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38350&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38350&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1041" NCI Thesaurus)

Legacy PDQ ID

10969

LT

TRD

NCI ID

C1041

notation

CDR0000038350

ORIG STY

Drug/agent

prefLabel

cefepime hydrochloride

tui

T109

T195

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http://purl.bioontology.org/ontology/SCTSPA/96048006 SCTSPA CUI
http://purl.bioontology.org/ontology/MESH/C043266 MESH CUI
http://purl.bioontology.org/ontology/MESH/C043266 MESH CUI
http://purl.bioontology.org/ontology/MESH/C043266 MESH CUI
http://purl.bioontology.org/ontology/SNOMEDCT/370371004 SNOMEDCT CUI
http://purl.jp/bio/4/id/200906005611016741 IOBC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/96048006 SNOMEDCT CUI
http://purl.bioontology.org/ontology/LNC/LP17165-9 LOINC CUI
http://purl.bioontology.org/ontology/RXNORM/20481 RXNORM CUI
http://purl.bioontology.org/ontology/LNC/MTHU008443 LOINC CUI
http://purl.bioontology.org/ontology/SCTSPA/370371004 SCTSPA CUI
http://purl.bioontology.org/ontology/NDFRT/N0000004493 NDFRT CUI
http://purl.obolibrary.org/obo/CHEBI_31368 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31368 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_31368 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_31368 DINTO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148397 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148397 NDFRT LOOM
http://purl.bioontology.org/ontology/VANDF/4024049 VANDF CUI
http://purl.bioontology.org/ontology/SNOMEDCT/370370003 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/370370003 SNOMEDCT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1041 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1041 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1041 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1041 NCIT LOOM
http://purl.bioontology.org/ontology/SCTSPA/370370003 SCTSPA CUI
http://purl.bioontology.org/ontology/VANDF/4020908 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4020908 VANDF LOOM
http://purl.bioontology.org/ontology/RXNORM/236058 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/236058 RXNORM LOOM
http://purl.bioontology.org/ontology/RXNORM/82808 RXNORM CUI
http://purl.bioontology.org/ontology/NDDF/004974 NDDF CUI
http://purl.bioontology.org/ontology/NDDF/004975 NDDF CUI
http://purl.bioontology.org/ontology/NDFRT/N0000022054 NDFRT CUI
http://purl.bioontology.org/ontology/SNMI/C-53590 SNMI CUI
http://purl.bioontology.org/ontology/SCTSPA/412602009 SCTSPA CUI
http://purl.bioontology.org/ontology/UATC/J01DE01 ATC CUI
http://purl.bioontology.org/ontology/SNOMEDCT/412602009 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/412602009 SNOMEDCT LOOM