loading...| Preferred Name |
levofloxacin |
|
| Synonyms |
Quixin |
|
| Definitions |
A broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1586" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1586" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000037941 |
|
| altLabel |
Quixin Levaquin |
|
| CAS Registry |
100986-85-4 |
|
| cui |
C0282386 C0721336 C0939461 |
|
| definition |
A broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1586" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1586" NCI Thesaurus) |
|
| Legacy PDQ ID |
10360 |
|
| LT |
TRD |
|
| NCI ID |
C1586 |
|
| notation |
CDR0000037941 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
levofloxacin |
|
| tui |
T109 T195 T121 |