Physician Data Query

Last uploaded: January 31, 2024
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Preferred Name

captopril
Synonyms

Capoten
Definitions

A sulfhydryl-containing analog of proline with antihypertensive activity and potential antineoplastic activity. Captopril competitively inhibits angiotensin converting enzyme (ACE), thereby decreasing levels of angiotensin II, increasing plasma renin activity, and decreasing aldosterone secretion. This agent may also inhibit tumor angiogenesis by inhibiting endothelial cell matrix metalloproteinases (MMPs) and endothelial cell migration. Captopril may also exhibit antineoplastic activity independent of effects on tumor angiogenesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C340" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C340" NCI Thesaurus)
ID

http://purl.bioontology.org/ontology/PDQ/CDR0000037824
altLabel

Capoten

(S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline

CPT
CAS Registry

62571-86-2
Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000347392
cui

C0591224

C0006938
Date last modified

2006-07-30
definition

A sulfhydryl-containing analog of proline with antihypertensive activity and potential antineoplastic activity. Captopril competitively inhibits angiotensin converting enzyme (ACE), thereby decreasing levels of angiotensin II, increasing plasma renin activity, and decreasing aldosterone secretion. This agent may also inhibit tumor angiogenesis by inhibiting endothelial cell matrix metalloproteinases (MMPs) and endothelial cell migration. Captopril may also exhibit antineoplastic activity independent of effects on tumor angiogenesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C340" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C340" NCI Thesaurus)
Legacy PDQ ID

10214
LT

TRD
NCI ID

C340
notation

CDR0000037824
ORIG STY

Drug/agent
prefLabel

captopril
tui

T116

T121
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http://purl.bioontology.org/ontology/SNMI/C-C13CC SNMI CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387160004 SNOMEDCT CUI
http://purl.bioontology.org/ontology/CSP/0777-7874 CRISP CUI
http://purl.bioontology.org/ontology/MESH/D002216 MESH CUI
http://purl.bioontology.org/ontology/RCD/x02Wf RCD CUI
http://purl.bioontology.org/ontology/LNC/LP32689-9 LOINC CUI
http://purl.bioontology.org/ontology/SNMI/C-80390 SNMI CUI
http://purl.bioontology.org/ontology/RXNORM/1998 RXNORM CUI
http://purl.bioontology.org/ontology/VANDF/4017614 VANDF CUI
http://purl.bioontology.org/ontology/SNOMEDCT/29439004 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SCTSPA/29439004 SCTSPA CUI
http://purl.bioontology.org/ontology/NDFRT/N0000007435 NDFRT CUI
http://purl.bioontology.org/ontology/LNC/MTHU006862 LOINC CUI
http://purl.bioontology.org/ontology/NDDF/000656 NDDF CUI
http://purl.bioontology.org/ontology/ATC/C09AA01 ATC CUI
http://purl.bioontology.org/ontology/SCTSPA/387160004 SCTSPA CUI
http://purl.bioontology.org/ontology/LNC/LP18914-9 LOINC CUI
http://purl.bioontology.org/ontology/CSP/0777-7874 CRISP CUI
http://purl.bioontology.org/ontology/RCD/bi1.. RCD CUI
http://purl.bioontology.org/ontology/NDFRT/N0000145994 NDFRT CUI
http://purl.bioontology.org/ontology/MSHFRE/D002216 MSHFRE CUI
http://purl.bioontology.org/ontology/MESH/D002216 MESH CUI
http://purl.obolibrary.org/obo/XCO_0000270 XCO LOOM
http://purl.obolibrary.org/obo/XCO_0000270 XCO LOOM
http://purl.obolibrary.org/obo/CHEBI_3380 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_3380 CHEBI LOOM
http://purl.obolibrary.org/obo/OMIT_0003555 OMIT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387160004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/LP32689-9 LOINC LOOM
http://purl.bioontology.org/ontology/SNMI/C-80390 SNMI LOOM
http://bmi.utah.edu/ontologies/hfontology/C0006938 HFO LOOM
http://www.phoc.org.cn/pmo/class/PMO_00021270 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/RXNORM/1998 NLMVS LOOM
http://purl.bioontology.org/ontology/RXNORM/1998 RXNORM LOOM
http://purl.obolibrary.org/obo/MESH_D002216 BERO LOOM
http://purl.bioontology.org/ontology/VANDF/4017614 VANDF LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#captopril SDO LOOM
http://www.co-ode.org/ontologies/galen#Captopril GALEN LOOM
http://stirdf.jst.go.jp/id/200907010005604619 IOBC LOOM
http://purl.jp/bio/4/id/200906011359955098 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0006938 OCHV LOOM
http://purl.bioontology.org/ontology/LNC/MTHU006862 LOINC LOOM
http://purl.obolibrary.org/obo/CHEBI_3380 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_3380 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_3380 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_3380 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_3380 COVID-19 LOOM
http://purl.obolibrary.org/obo/CHEBI_3380 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_3380 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_3380 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_3380 CIDO LOOM
http://purl.obolibrary.org/obo/CHEBI_3380 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_3380 HINO LOOM
http://purl.bioontology.org/ontology/NDDF/000656 NDDF LOOM
http://purl.obolibrary.org/obo/NCIT_C340 BERO LOOM
http://purl.bioontology.org/ontology/ATC/C09AA01 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.125.072.401.623.270 RH-MESH LOOM
https://go.drugbank.com/drugs/DB01197 MDM LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C340 NCIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002216 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/LP18914-9 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#2377 OCHV LOOM
http://purl.bioontology.org/ontology/CSP/0777-7874 CRISP LOOM
http://www.drugbank.ca/drugs/DB01197 FTC LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Captopril APAONTO LOOM
http://purl.bioontology.org/ontology/RCD/bi1.. RCD LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000145994 OCVDAE LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02619 MIO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000145994 NDFRT LOOM
http://purl.bioontology.org/ontology/MESH/D002216 MESH LOOM
http://scai.fraunhofer.de/AlzheimerOntology#captopril ADO LOOM