Parkinson's Disease Ontology

Last uploaded: August 18, 2014
Preferred Name

Manganese

Synonyms
ID

http://www.semanticweb.org/ontologies/2011/1/Ontology1296772722296.owl#Manganese

isDefinedBy

Manganese can cause manganism, an irreversible neurological disorder similar to Parkinson's disease. Occupational exposures occur mainly in welding, mining as miners are surrounded by manganese dust and airborne manganese particles, alloy production, processing, ferro-manganese operations especially in which manganese ore or manganese compounds are turned into steel, and work with agrochemicals. The towns and communities surrounding the areas of manganese heavy industry could also become affected by toxic exposure to manganese. It is also hypothesized that long-term exposure to the naturally-occurring manganese in shower water also puts people at risk. Manganese inhibits tyrosine hydroxylation, which is essential for the formation of dopamine. So manganese may cause Parkinson's disease by lowering dopamine levels.

label

Manganese

prefixIRI

Manganese

prefLabel

Manganese

Reference

Jankovic, J. J. T. E., & Tolosa. (2007). Parkinson's disease and movement disorders. E. Tolosa (Ed.). Lippincott Williams & Wilkins.

subClassOf

http://www.semanticweb.org/ontologies/2011/1/Ontology1296772722296.owl#Toxin_cause_of_parkinsonism

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http://vocabs.lter-europe.net/EnvThes/USLterCV_321 ENVTHES LOOM
http://vocabs.lter-europe.net/EnvThes/20830 ENVTHES LOOM
http://purl.bioontology.org/ontology/MESH/D008345 MESH LOOM
http://purl.jp/bio/4/id/200906073838884982 IOBC LOOM
http://www.cea.fr/ontotoxnuc#Manganese ONTOTOXNUC LOOM
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http://purl.bioontology.org/ontology/npo#NPO_324 ENM LOOM
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http://purl.bioontology.org/ontology/SNOMEDCT/87869004 SNOMEDCT LOOM
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http://www.projecthalo.com/aura#Manganese AURA LOOM
http://purl.bioontology.org/ontology/NDDF/000856 NDDF LOOM
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http://www.co-ode.org/ontologies/galen#Manganese GALEN LOOM
https://go.drugbank.com/drugs/DB06757 MDM LOOM
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http://phenomebrowser.net/ontologies/mesh/mesh.owl#D008345 RH-MESH LOOM
http://purl.bioontology.org/ontology/CSP/1852-8510 CRISP LOOM