Prostate Cancer Ontology

Last uploaded: June 6, 2023
Preferred Name

Leuprolide

Synonyms
Definitions

A synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression./NCI-GLOSS Definition: The active ingredient in a drug used to treat symptoms of advanced prostate cancer. It is also used to treat early puberty in children and certain gynecologic conditions. It is being studied in the treatment of other conditions and types of cancer. Leuprolide blocks the body from making testosterone (a male hormone) and estradiol (a female hormone). It may stop the growth of prostate cancer cells that need testosterone to grow. It is a type of gonadotropin-releasing hormone analog.

ID

http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#leuprorelin

definition

A synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression./NCI-GLOSS Definition: The active ingredient in a drug used to treat symptoms of advanced prostate cancer. It is also used to treat early puberty in children and certain gynecologic conditions. It is being studied in the treatment of other conditions and types of cancer. Leuprolide blocks the body from making testosterone (a male hormone) and estradiol (a female hormone). It may stop the growth of prostate cancer cells that need testosterone to grow. It is a type of gonadotropin-releasing hormone analog.

label

Leuprolide

prefixIRI

ProstateCancer:leuprorelin

prefLabel

Leuprolide

reference

NCI Thesaurus Code:C62042

synonyms

6-D-Leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide Luteinizing Hormone-Releasing Factor (Pig)

6-D-Leucine-9-(N-ethyl-L-prolinamide)-1-9-luteinizing Hormone-releasing Factor (Pig)

Leuprorelin

LEUPROLIDE

Leuprolide

leuprolide

URL

https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C62042

subClassOf

http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Medical_Castration

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http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62042 NCIT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#15531 OCHV LOOM
http://purl.obolibrary.org/obo/OMIT_0017176 OMIT LOOM
http://purl.bioontology.org/ontology/CSP/4000-0227 CRISP LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.641.650.405.740.320.400 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/42375 RXNORM LOOM
http://www.phoc.org.cn/pmo/class/PMO_00019103 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/NCIT_C62042 BERO LOOM
http://purl.jp/bio/4/id/200906006950029492 IOBC LOOM
http://purl.obolibrary.org/obo/CHEBI_6427 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_6427 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_6427 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_6427 GSSO LOOM
http://purl.obolibrary.org/obo/CHEBI_6427 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_6427 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6427 ODNAE LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D016729 RH-MESH LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147889 ODAE LOOM
https://go.drugbank.com/drugs/DB00007 MDM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.400.400.740.320.400 RH-MESH LOOM
http://www.drugbank.ca/drugs/DB00007 FTC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D06.472.699.327.740.320.400 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/004751 NDDF LOOM
http://purl.bioontology.org/ontology/LNC/LP172752-0 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.456.460.480 RH-MESH LOOM
http://purl.obolibrary.org/obo/MESH_D016729 BERO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147889 NDFRT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/397198002 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4019800 VANDF LOOM
http://purl.bioontology.org/ontology/MESH/D016729 MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0085272 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.548.365.740.320.400 RH-MESH LOOM