Prostate Cancer Ontology

Last uploaded: June 6, 2023
Preferred Name

Enzalutamide

Synonyms
Definitions

An orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Through a mechanism that is reported to be different from other approved AR antagonists, enzalutamide inhibits the activity of prostate cancer cell ARs, which may result in a reduction in prostate cancer cell proliferation and, correspondingly, a reduction in the serum prostate specific antigen (PSA) level. AR over-expression in prostate cancer represents a key mechanism associated with prostate cancer hormone resistance.

ID

http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Enzalutamide_hormonal_drug

ChineseLabel

安扎鲁胺

definition

An orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Through a mechanism that is reported to be different from other approved AR antagonists, enzalutamide inhibits the activity of prostate cancer cell ARs, which may result in a reduction in prostate cancer cell proliferation and, correspondingly, a reduction in the serum prostate specific antigen (PSA) level. AR over-expression in prostate cancer represents a key mechanism associated with prostate cancer hormone resistance.

label

Enzalutamide

prefixIRI

ProstateCancer:Enzalutamide_hormonal_drug

prefLabel

Enzalutamide

reference

NCI Thesaurus Code:C71744

synonyms

Enzalutamide

Benzamide, 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl)-2-fluoro-N-methyl-

ENZALUTAMIDE

ASP9785

MDV3100

Xtandi

URL

https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71744

subClassOf

http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Hormonal_drugs_targeting_the_endocrine_pathways_in_the_pre-docetaxel_space

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