Prostate Cancer Ontology

Last uploaded: June 6, 2023
Preferred Name

Alpha-tocopherol

Synonyms
Definitions

The orally bioavailable alpha form of the naturally-occurring fat-soluble vitamin E, with potent antioxidant and cytoprotective activities. Upon administration, alpha-tocopherol neutralizes free radicals, thereby protecting tissues and organs from oxidative damage. Alpha-tocopherol gets incorporated into biological membranes, prevents protein oxidation and inhibits lipid peroxidation, thereby maintaining cell membrane integrity and protecting the cell against damage. In addition, alpha-tocopherol inhibits the activity of protein kinase C (PKC) and PKC-mediated pathways. Alpha-tocopherol also modulates the expression of various genes, plays a key role in neurological function, inhibits platelet aggregation and enhances vasodilation. Compared with other forms of tocopherol, alpha-tocopherol is the most biologically active form and is the form that is preferentially absorbed and retained in the body. CRCH Definition: Tocopherol with three methyl groups on its chromanol ring."

ID

http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Alpha-tocopherol

ChineseLabel

α-生育酚

definition

The orally bioavailable alpha form of the naturally-occurring fat-soluble vitamin E, with potent antioxidant and cytoprotective activities. Upon administration, alpha-tocopherol neutralizes free radicals, thereby protecting tissues and organs from oxidative damage. Alpha-tocopherol gets incorporated into biological membranes, prevents protein oxidation and inhibits lipid peroxidation, thereby maintaining cell membrane integrity and protecting the cell against damage. In addition, alpha-tocopherol inhibits the activity of protein kinase C (PKC) and PKC-mediated pathways. Alpha-tocopherol also modulates the expression of various genes, plays a key role in neurological function, inhibits platelet aggregation and enhances vasodilation. Compared with other forms of tocopherol, alpha-tocopherol is the most biologically active form and is the form that is preferentially absorbed and retained in the body. CRCH Definition: Tocopherol with three methyl groups on its chromanol ring."

label

Alpha-tocopherol

prefixIRI

ProstateCancer:Alpha-tocopherol

prefLabel

Alpha-tocopherol

reference

NCI Thesaurus Code:C74960

synonyms

Alpha-Tocopherol

3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol

Alpha-tocopherol

ALPHA.-TOCOPHEROL

2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol

URL

https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C74960

subClassOf

http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Additives

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http://purl.obolibrary.org/obo/XCO_0000379 XCO LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_4a54ac46_c5aa_4937_afae_4103e8fc9f79 STO-DRAFT LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_4a54ac46_c5aa_4937_afae_4103e8fc9f79 CVAO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0969677 OCHV LOOM
http://purl.obolibrary.org/obo/CHEBI_46430 BIOMODELS LOOM
http://purl.bioontology.org/ontology/MEDLINEPLUS/C0969677 MEDLINEPLUS LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C74960 NCIT LOOM
http://purl.obolibrary.org/obo/NCIT_C74960 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D024502 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/LP15369-9 LOINC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/259666007 SNOMEDCT LOOM
https://www.fns-cloud.eu/foodComponents/FNS_H_0000003462 FNS-H LOOM
http://purl.obolibrary.org/obo/CHEBI_22470 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_22470 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_22470 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_22470 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_22470 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_22470 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_22470 UPHENO LOOM
http://purl.obolibrary.org/obo/CHEBI_22470 ONSTR LOOM
http://purl.obolibrary.org/obo/CHEBI_22470 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_22470 ZP LOOM
http://purl.obolibrary.org/obo/MESH_D024502 BERO LOOM
http://purl.bioontology.org/ontology/MESH/D024502 MESH LOOM
http://purl.bioontology.org/ontology/RCD/X80Re RCD LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017676 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/OMIT_0021058 OMIT LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000775583 PDQ LOOM
http://stirdf.jst.go.jp/id/200907037405731488 IOBC LOOM
http://www.ustb.edu.cn/thesauri/tocr/v1/data#C571347974240596057 ACVD_ONTOLOGY LOOM
http://purl.obolibrary.org/obo/CHEBI_18145 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_18145 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_18145 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_18145 DRON LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.150.909.750.249 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/237099 RXNORM LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004905 LOINC LOOM
http://purl.jp/bio/4/id/200906044506089488 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.830.219.909.750.249 RH-MESH LOOM