Prostate Cancer Ontology

Last uploaded: June 3, 2019
Preferred Name

Abarelix

ID

http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Abarelix

ChineseLabel

阿巴瑞克

isDefinedBy

A synthetic decapeptide and antagonist of naturally occurring gonadotropin-releasing hormone (GnRH). Abarelix directly and competitively binds to and blocks the gonadotropin releasing hormone receptor in the anterior pituitary gland, thereby inhibiting the secretion and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). In males, the inhibition of LH secretion prevents the release of testosterone. As a result, this may relieve symptoms associated with prostate hypertrophy or prostate cancer, since testosterone is required to sustain prostate growth./NCI-GLOSS Definition: A drug used to reduce the amount of testosterone made in patients with advanced symptomatic prostate cancer for which no other treatment options are available. It belongs to the family of drugs called gonadotropin-releasing hormone (GnRH) antagonists.

label

Abarelix

prefixIRI

ProstateCancer:Abarelix

prefLabel

Abarelix

reference

NCI Thesaurus Code:C2015

synonyms

Abarelix

Plenaxis

R-3827

ABARELIX

abarelix/

PPI-149

URL

https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2015

subClassOf

http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Luteinising-hormone-releasing_hormone_antagonists

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