American trypanosomiasis

Chagas disease

A tropical disease mainly found in latin America and transmitted by triatomine insects (mostly <i>Triatoma infestans</i> and <i>Rhodnius prolixus</i> and <i>Panstrongylus megistus</i>) harboring the hemoflagellate protozoan parasite <i>Trypanosoma cruzi</i>. The disease is characterized by an acute phase which is either asymptomatic or manifest with fever, inflammation at the inoculation site (inoculation chancre or chagoma), unilateral palpebral edema called the Romaña sign (when the triatomine bite occurs near the eye), enlarged lymph nodes, and splenomegaly. The chronic phase is lifelong and development of chagasic cardiomyopathy (30%; complex arrhythmias, heart failure, and thromboembolic events), digestive (10%; megaoesophagus and megacolon), neurological (10%; stroke, peripheral neuropathy and autonomic dysfunction), or mixed alterations (10%) may be observed. These can all lead to high morbidity and mortality rates.

http://www.orpha.net/ORDO/Orphanet_3386

Chagas disease

A tropical disease mainly found in latin America and transmitted by triatomine insects (mostly Triatoma infestans and Rhodnius prolixus and Panstrongylus megistus) harboring the hemoflagellate protozoan parasite Trypanosoma cruzi. The disease is characterized by an acute phase which is either asymptomatic or manifest with fever, inflammation at the inoculation site (inoculation chancre or chagoma), unilateral palpebral edema called the Romaña sign (when the triatomine bite occurs near the eye), enlarged lymph nodes, and splenomegaly. The chronic phase is lifelong and development of chagasic cardiomyopathy (30%; complex arrhythmias, heart failure, and thromboembolic events), digestive (10%; megaoesophagus and megacolon), neurological (10%; stroke, peripheral neuropathy and autonomic dysfunction), or mixed alterations (10%) may be observed. These can all lead to high morbidity and mortality rates.

Orphanet

https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=3386

All ages

Not applicable

ICD-10:B57.1

MeSH:D014355

ICD-10:B57.0

ICD-10:B57.5

ICD-10:B57.3

ICD-10:B57.4

MedDRA:10001935

ICD-11:1F53

ICD-11:IF53.Y

ICD-11:1F53.4

ICD-11:1F53.3

ICD-11:1F53.1

ICD-11:1F53.2

UMLS:C0041234

ICD-10:B57.2

American trypanosomiasis

ORPHA:3386

http://www.orpha.net/ORDO/Orphanet_163588

ORDO:Orphanet_3386

American trypanosomiasis

Germany AND has_point_prevalence_range : <1 / 1 000 000

Netherlands AND has_point_prevalence_range : <1 / 1 000 000

Spain AND has_point_prevalence_range : 1-9 / 100 000

Europe AND has_point_prevalence_range : 1-9 / 1 000 000

Italy AND has_point_prevalence_range : 1-9 / 1 000 000

Switzerland AND has_point_prevalence_range : 1-9 / 100 000

United Kingdom AND has_point_prevalence_range : <1 / 1 000 000

Portugal AND has_point_prevalence_range : <1 / 1 000 000

France AND has_point_prevalence_range : 1-9 / 1 000 000

Belgium AND has_point_prevalence_range : 1-9 / 1 000 000

United States AND has_point_prevalence_average_value : 95.0 AND has_point_prevalence_range : 6-9 / 10 000

http://www.orpha.net/ORDO/Orphanet_163588

http://www.orpha.net/ORDO/Orphanet_377788

http://www.orpha.net/ORDO/Orphanet_557493