Preferred Name |
Simvastatin |
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Synonyms |
[1S-[1alpha,3alpha,7beta,8beta(2S*,4S*),8abeta]]-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydr |
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Definitions |
A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL. (source : MSH) |
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ID |
http://doe-generated-ontology.com/OntoAD#C0074554 |
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altLabel |
[1S-[1alpha,3alpha,7beta,8beta(2S*,4S*),8abeta]]-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydr Velastatin Synvinolin HMG-CoA reductase inhibitors simvastatin |
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contraindicated_drug | ||
definition |
A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL. (source : MSH) |
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hiddenLabel |
Simvastatine Simvastatin |
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may_prevent | ||
may_treat | ||
prefixIRI |
OntoAD:C0074554 |
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prefLabel |
Simvastatine Simvastatin |
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subClassOf |