Preferred Name

Cardiac Glycosides

Synonyms

glucoside cardiaque

Cardiotonic Steroids

Cardiac Glycoside

Definitions

Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose. (source : MSH)

ID

http://doe-generated-ontology.com/OntoAD#C0007158

altLabel

glucoside cardiaque

Cardiotonic Steroids

Glycoside

glucoside

Hétérosides cardiotoniques

Cardiac Glycoside

definition

Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose. (source : MSH)

hiddenLabel

CardiacGlycosides

GlucosidesCardiotoniques

prefixIRI

OntoAD:C0007158

prefLabel

Cardiac Glycosides

Glucosides cardiotoniques

subClassOf

http://doe-generated-ontology.com/OntoAD#C0014432

http://doe-generated-ontology.com/OntoAD#C0007004

http://doe-generated-ontology.com/OntoAD#C1320237

http://doe-generated-ontology.com/OntoAD#C0007209

http://doe-generated-ontology.com/OntoAD#C0003195

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