Preferred Name |
Cardiac Glycosides |
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Synonyms |
glucoside cardiaque Cardiotonic Steroids Cardiac Glycoside |
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Definitions |
Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose. (source : MSH) |
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ID |
http://doe-generated-ontology.com/OntoAD#C0007158 |
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altLabel |
glucoside cardiaque Cardiotonic Steroids Glycoside glucoside Hétérosides cardiotoniques Cardiac Glycoside |
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definition |
Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose. (source : MSH) |
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hiddenLabel |
CardiacGlycosides GlucosidesCardiotoniques |
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prefixIRI |
OntoAD:C0007158 |
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prefLabel |
Cardiac Glycosides Glucosides cardiotoniques |
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subClassOf |
http://doe-generated-ontology.com/OntoAD#C0014432 http://doe-generated-ontology.com/OntoAD#C0007004 http://doe-generated-ontology.com/OntoAD#C1320237 |