Preferred Name |
paroxetine |
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Synonyms |
Paroxetine (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine C19H20FNO3 paroxetinum [H][C@]1(CCNC[C@H]1COc1ccc2OCOc2c1)c1ccc(F)cc1 InChIKey=AHOUBRCZNHFOSL-YOEHRIQHSA-N (-)-(3S,4R)-4-(p-fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine paroxetina (3S-trans)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine InChI=1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2/t14-,17-/m0/s1 |
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Definitions |
A benzodioxole that consists of piperidine bearing 1,3-benzodioxol-5-yloxy)methyl and 4-fluorophenyl substituents at positions 3 and 4 respectively; the (3S,4R)-diastereomer. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo. |
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ID |
http://purl.obolibrary.org/obo/CHEBI_7936 |
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database_cross_reference |
CiteXplore:22240860 CiteXplore:14521492 CiteXplore:17452166 CiteXplore:11009210 CiteXplore:17612590 CiteXplore:17162096 CiteXplore:14566196 CiteXplore:15963219 CiteXplore:19851065 CiteXplore:11910269 Beilstein:7467879 CiteXplore:15241233 CiteXplore:14566200 Wikipedia:Paroxetine CiteXplore:16765127 CiteXplore:12820211 CiteXplore:18273418 CiteXplore:17219219 CiteXplore:22153922 CiteXplore:15845695 CiteXplore:18983224 CiteXplore:11819027 CiteXplore:11513198 CiteXplore:21939725 CiteXplore:11893234 CiteXplore:15853570 CiteXplore:15613191 CiteXplore:15264994 CiteXplore:14516531 CiteXplore:14978354 KEGG COMPOUND:61869-08-7 CiteXplore:12906023 CiteXplore:21452176 CiteXplore:17559097 CiteXplore:14689334 CiteXplore:15903129 CiteXplore:22263916 CiteXplore:21404089 CiteXplore:17286545 CiteXplore:15544025 CiteXplore:11271409 CiteXplore:15199661 CiteXplore:14673053 CiteXplore:15376524 CiteXplore:12369443 CiteXplore:15374134 CiteXplore:12421645 CiteXplore:22353759 CiteXplore:11565622 CiteXplore:18808757 CiteXplore:22377745 CiteXplore:17122538 CiteXplore:22283559 CiteXplore:12818234 CiteXplore:16395417 ChemIDplus:61869-08-7 CiteXplore:16822276 CiteXplore:19687003 CiteXplore:21909633 CiteXplore:22198456 CiteXplore:12027788 CiteXplore:11324355 CiteXplore:11360029 DrugBank:DB00715 CiteXplore:15992089 CiteXplore:21922171 CiteXplore:15048901 CiteXplore:16913391 CiteXplore:12920419 KEGG COMPOUND:C07415 Reaxys:7467879 CiteXplore:17652957 CiteXplore:17874333 CiteXplore:16426087 CiteXplore:11281965 CiteXplore:14624192 CiteXplore:18345955 CiteXplore:14619895 CiteXplore:16397315 CiteXplore:12088162 KEGG DRUG:D02362 CiteXplore:22212003 CiteXplore:11563413 CiteXplore:11169163 CiteXplore:21739267 CiteXplore:21908494 |
|
definition |
A benzodioxole that consists of piperidine bearing 1,3-benzodioxol-5-yloxy)methyl and 4-fluorophenyl substituents at positions 3 and 4 respectively; the (3S,4R)-diastereomer. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo. |
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has_exact_synonym |
Paroxetine (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine |
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has_related_synonym |
C19H20FNO3 paroxetinum [H][C@]1(CCNC[C@H]1COc1ccc2OCOc2c1)c1ccc(F)cc1 InChIKey=AHOUBRCZNHFOSL-YOEHRIQHSA-N (-)-(3S,4R)-4-(p-fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine paroxetina (3S-trans)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine InChI=1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2/t14-,17-/m0/s1 |
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has_RxCUI |
32937 |
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id |
CHEBI:7936 |
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imported from | ||
label |
Paroxetine paroxetine |
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notation |
CHEBI:7936 |
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prefLabel |
paroxetine |
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subClassOf |
http://purl.obolibrary.org/obo/CHEBI_35618 http://purl.obolibrary.org/obo/CHEBI_37143 |