Ontology of Drug Adverse Events

Last uploaded: January 12, 2019
Preferred Name

paired limb/fin bud

Synonyms

paired limb/fin bud

limb - fin bud

paired appendage bud

Definitions

An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP]. Genes: In limb buds of chick and mouse, Shh expression is activated as soon as there is a morphological bud, whereas in S. canicula fin buds, consistent with reported data in other cartilaginous fishes, Shh is transcribed late in fin development[PMID:17187056]

ID

http://purl.obolibrary.org/obo/UBERON_0004357

comment

Genes: In limb buds of chick and mouse, Shh expression is activated as soon as there is a morphological bud, whereas in S. canicula fin buds, consistent with reported data in other cartilaginous fishes, Shh is transcribed late in fin development[PMID:17187056]

database_cross_reference

VHOG:0001258

has developmental contribution from

http://purl.obolibrary.org/obo/UBERON_0005732

has exact synonym

paired limb/fin bud

limb - fin bud

paired appendage bud

has part

http://purl.obolibrary.org/obo/UBERON_0004356

has potential to develop into

http://purl.obolibrary.org/obo/UBERON_0004708

has_obo_namespace

uberon

homology_notes

The tetrapod limb is derived from a posterior part of the fin endoskeleton of elasmobranchs and basal bony fish, the so-called metapterygium, a series of endoskeletal elements that is the first to form in the developing paired fins. (...) In addition, there is an independent endoskeletal element called the protopterygium that develops anterior to the metapterygium in many basal fishes (e.g., the bichir and sturgeon). Teleosts have lost the metapterygium whereas the sarcopterygians, on the other hand, have lost the protopterygium. Sarcopterygians thus develop all their endoskeletal structures from the metapterygium and consequently the tetrapod limb skeleton is derived from the metapterygium.[uncertain][VHOG]

id

UBERON:0004357

imported from

http://purl.obolibrary.org/obo/uberon.owl

http://purl.obolibrary.org/obo/oae.owl

in_subset

http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#homology_grouping

label

paired limb/fin bud

notation

UBERON:0004357

part_of

http://purl.obolibrary.org/obo/UBERON_0000922

prefLabel

paired limb/fin bud

textual definition

An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP].

treeView

http://purl.obolibrary.org/obo/UBERON_0000922

subClassOf

http://purl.obolibrary.org/obo/UBERON_0006598

http://purl.obolibrary.org/obo/UBERON_0003102

http://purl.obolibrary.org/obo/UBERON_0002050

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Delete Mapping To Ontology Source
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