NanoParticle Ontology

Last uploaded: August 17, 2012
Preferred Name

methotrexate

Synonyms
Definitions

An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. <ncicp:ComplexDefinition><ncicp:def-definition>A pteridine compound has a pteridine substructure; which has functional parent, L-glutamic acid; which has other substructures that classify it a monocarboxylic acid amide and a dicarboxylic acid.</ncicp:def-definition></ncicp:ComplexDefinition>

ID

http://purl.org/obo/owl/CHEBI#CHEBI_44185

comment

An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear.

code

NPO_741

dBXrefID

CHEBI:44185

NCIT:C642

definition

<ncicp:ComplexDefinition><ncicp:def-definition>A pteridine compound has a pteridine substructure; which has functional parent, L-glutamic acid; which has other substructures that classify it a monocarboxylic acid amide and a dicarboxylic acid.</ncicp:def-definition></ncicp:ComplexDefinition>

label

methotrexate

preferred_name

methotrexate

prefixIRI

CHEBI:CHEBI_44185

subClassOf

http://purl.org/obo/owl/CHEBI#CHEBI_32877

http://purl.org/obo/owl/CHEBI#CHEBI_33575

http://purl.org/obo/owl/CHEBI#CHEBI_26373

http://purl.org/obo/owl/CHEBI#CHEBI_37622

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_44185 OBA LOOM
http://purl.obolibrary.org/obo/CHEBI_44185 FYPO LOOM
http://purl.bioontology.org/ontology/SNMI/C-78170 SNMI LOOM
http://www.semanticweb.org/dellvostro3750/ontologies/2018/2/untitled-ontology-10#methotrexate HP_O LOOM
http://purl.bioontology.org/ontology/MESH/D008727 MESH LOOM
http://purl.bioontology.org/ontology/ATC/L01BA01 ATC LOOM
http://purl.obolibrary.org/obo/CHEBI_44185 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_44185 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_44185 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_44185 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_44185 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_44185 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_44185 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_44185 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_44185 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_44185 OBA LOOM
http://purl.obolibrary.org/obo/CHEBI_44185 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_44185 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_44185 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_44185 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_44185 ODNAE LOOM
http://bmi.utah.edu/ontologies/peontology/C0025677 RAO LOOM
http://purl.obolibrary.org/obo/OMIT_0009786 OMIT LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02537 MIO LOOM
http://purl.jp/bio/4/id/200906002710798892 IOBC LOOM
http://purl.bioontology.org/ontology/ATC/L04AX03 ATC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000041719 PDQ LOOM
http://purl.bioontology.org/ontology/RCD/h34.. RCD LOOM
http://stirdf.jst.go.jp/id/200907053089575288 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4019828 VANDF LOOM
http://purl.bioontology.org/ontology/LNC/LP16198-1 LOINC LOOM
http://purl.obolibrary.org/obo/NCIT_C642 BERO LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147916 ODAE LOOM
http://www.drugbank.ca/drugs/DB00563 FTC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C642 NCIT LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017772 PMAPP-PMO LOOM
https://github.com/sap218/coid/blob/master/coid.owl#COID_00469 COID LOOM
http://purl.bioontology.org/ontology/CSP/1175-1202 CRISP LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0025677 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.733.631.192.500 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#8044 OCHV LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147916 NDFRT LOOM
http://purl.bioontology.org/ontology/LNC/LA14339-8 LOINC LOOM
https://github.com/sap218/ocimido/blob/master/ontology/ocimido.owl#OCIMIDO_00181 OCIMIDO LOOM
http://purl.obolibrary.org/obo/ARO_3007096 ARO LOOM
http://localhost/plosthes.2017-1#5614 PLOSTHES LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D008727 RH-MESH LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClassb1cefdd0_4663_4764_90f3_d06fe0ae1d37 WWECA LOOM
https://go.drugbank.com/drugs/DB00563 MDM LOOM
http://purl.bioontology.org/ontology/NDDF/002644 NDDF LOOM
http://purl.obolibrary.org/obo/MESH_D008727 BERO LOOM
http://purl.obolibrary.org/obo/dinto_1762 DINTO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387381009 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RXNORM/6851 RXNORM LOOM
http://purl.bioontology.org/ontology/LNC/MTHU005020 LOINC LOOM
http://ontology.lst.tfo.upm.es/SPT/chemo#Cancer_Therapy_Agent_Name@@9 HENEGEO LOOM
http://www.gamuts.net/entity#methotrexate GAMUTS LOOM
http://scai.fraunhofer.de/MSOntology#Methotrexate MSO LOOM
http://www.co-ode.org/ontologies/galen#Methotrexate GALEN LOOM