Preferred Name |
methotrexate |
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Synonyms |
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Definitions |
An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. <ncicp:ComplexDefinition><ncicp:def-definition>A pteridine compound has a pteridine substructure; which has functional parent, L-glutamic acid; which has other substructures that classify it a monocarboxylic acid amide and a dicarboxylic acid.</ncicp:def-definition></ncicp:ComplexDefinition> |
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ID |
http://purl.org/obo/owl/CHEBI#CHEBI_44185 |
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comment |
An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. |
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code |
NPO_741 |
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dBXrefID |
CHEBI:44185 NCIT:C642 |
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definition |
<ncicp:ComplexDefinition><ncicp:def-definition>A pteridine compound has a pteridine substructure; which has functional parent, L-glutamic acid; which has other substructures that classify it a monocarboxylic acid amide and a dicarboxylic acid.</ncicp:def-definition></ncicp:ComplexDefinition> |
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label |
methotrexate |
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preferred_name |
methotrexate |
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prefixIRI |
CHEBI:CHEBI_44185 |
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subClassOf |
http://purl.org/obo/owl/CHEBI#CHEBI_32877 http://purl.org/obo/owl/CHEBI#CHEBI_33575 |