loading...| Preferred Name |
cetuximab |
|
| Synonyms |
Erbitux |
|
| Definitions |
drug directed against extracellular domain of membrane receptor <ncicp:ComplexDefinition><ncicp:def-definition>A recombinant, chimeric monoclonal antibody directed against the epidermal growth factor receptor (EGFR) with antineoplastic activity. Cetuximab binds to the extracellular domain of the EGFR, thereby preventing the activation and subsequent dimerization of the receptor; the decrease in receptor activation and dimerization may result in an inhibition in signal transduction and anti-proliferative effects. This agent may inhibit EGFR-dependent primary tumor growth and metastasis. EGFR is overexpressed on the cell surfaces of various solid tumors.[source: NCI_Thesaurus]</ncicp:def-definition></ncicp:ComplexDefinition> |
|
| ID |
http://purl.bioontology.org/ontology/npo#NPO_577 |
|
| comment |
drug directed against extracellular domain of membrane receptor |
|
| code |
NPO_577 |
|
| dBXrefID |
NCIT:C1723 |
|
| definition |
<ncicp:ComplexDefinition><ncicp:def-definition>A recombinant, chimeric monoclonal antibody directed against the epidermal growth factor receptor (EGFR) with antineoplastic activity. Cetuximab binds to the extracellular domain of the EGFR, thereby preventing the activation and subsequent dimerization of the receptor; the decrease in receptor activation and dimerization may result in an inhibition in signal transduction and anti-proliferative effects. This agent may inhibit EGFR-dependent primary tumor growth and metastasis. EGFR is overexpressed on the cell surfaces of various solid tumors.[source: NCI_Thesaurus]</ncicp:def-definition></ncicp:ComplexDefinition> |
|
| label |
cetuximab |
|
| preferred_name |
cetuximab |
|
| prefixIRI |
npo:NPO_577 |
|
| synonym |
Erbitux |
|
| subClassOf |