loading...| Preferred Name |
Lambert-Eaton Myasthenic Syndrome |
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| Synonyms |
Eaton-Lambert Syndrome Lambert-Eaton Syndrome Myasthenic-Myopathic Syndrome of Lambert-Eaton Lambert-Eaton's Syndrome Myasthenic-Myopathic Syndrome of Eaton-Lambert Eaton-Lambert Myasthenic Syndrome |
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| Definitions |
An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve (MeSH). |
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| ID |
http://uri.neuinfo.org/nif/nifstd/birnlex_12592 |
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| createdDate |
2007-10-05 |
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| definingCitation |
Adams et al., Principles of Neurology, 6th ed, pp 1471 |
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| definingCitationURI |
http://www.ninds.nih.gov/disorders/lambert_eaton/lambert_eaton.htm |
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| definition |
An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve (MeSH). |
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| hasBirnlexCurator | ||
| hasCurationStatus | ||
| hasDefinitionSource | ||
| hasExternalSource | ||
| label |
Lambert-Eaton Myasthenic Syndrome |
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| MeshUid |
D015624 |
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| modifiedDate |
2007-10-05 |
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| nifID |
_8.3_9.2 |
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| preferred label |
Lambert-Eaton Myasthenic Syndrome |
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| synonym |
Eaton-Lambert Syndrome Lambert-Eaton Syndrome Myasthenic-Myopathic Syndrome of Lambert-Eaton Lambert-Eaton's Syndrome Myasthenic-Myopathic Syndrome of Eaton-Lambert Eaton-Lambert Myasthenic Syndrome |
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| subClassOf |