loading...| Preferred Name |
Ketamine |
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| Synonyms |
(S)-Ketamine Esketamine Ketalar SV CI 581 base Ketanest Ketamine HCL (S)-(-)-Ketamine Ketalar l-Ketamine CLSTA 20 (-)-Ketamine Ketamine Base Ketalar base Ketaject Ketolar |
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| Definitions |
A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (receptors, N-methyl-D-aspartate) and may interact with sigma receptors. (PubChem) Pharmacology: Ketamine is a rapid-acting general anesthetic producing an anesthetic state characterized by profound analgesia, normal pharyngeal-laryngeal reflexes, normal or slightly enhanced skeletal muscle tone, cardiovascular and respiratory stimulation, and occasionally a transient and minimal respiratory depression. Ketamine is indicated as the sole anesthetic agent for diagnostic and surgical procedures that do not require skeletal muscle relaxation. The anesthetic state produced by Ketamine has been termed dissociative anesthesia in that it appears to selectively interrupt association pathways of the brain before producing somesthetic sensory blockade. It may selectively depress the thalamoneocortical system before significantly obtunding the more ancient cerebral centers and pathways (reticularactivating and limbic systems). Mechanism of action: Ketamine has several clinically useful properties, including analgesia and less cardiorespiratory depressant effects than other anaesthetic agents, it also causes some stimulation of the cardiocascular system. Ketamine has been reported to produce general as well as local anaesthesia. It interacts with N-methyl-D-aspartate (NMDA) receptors, opioid receptors, monoaminergic receptors, muscarinic receptors and voltage sensitive Ca ion channels. Unlike other general anaesthetic agents, ketamine does not interact with GABA receptors. Drug type: Approved. Small Molecule. Drug category: Analgesics. Anesthetics, Dissociative. Excitatory Amino Acid Antagonists. General Anesthetics |
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| ID |
http://uri.neuinfo.org/nif/nifstd/DB01221 |
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| createdDate |
March 5, 2010 |
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| definition |
A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (receptors, N-methyl-D-aspartate) and may interact with sigma receptors. (PubChem) Pharmacology: Ketamine is a rapid-acting general anesthetic producing an anesthetic state characterized by profound analgesia, normal pharyngeal-laryngeal reflexes, normal or slightly enhanced skeletal muscle tone, cardiovascular and respiratory stimulation, and occasionally a transient and minimal respiratory depression. Ketamine is indicated as the sole anesthetic agent for diagnostic and surgical procedures that do not require skeletal muscle relaxation. The anesthetic state produced by Ketamine has been termed dissociative anesthesia in that it appears to selectively interrupt association pathways of the brain before producing somesthetic sensory blockade. It may selectively depress the thalamoneocortical system before significantly obtunding the more ancient cerebral centers and pathways (reticularactivating and limbic systems). Mechanism of action: Ketamine has several clinically useful properties, including analgesia and less cardiorespiratory depressant effects than other anaesthetic agents, it also causes some stimulation of the cardiocascular system. Ketamine has been reported to produce general as well as local anaesthesia. It interacts with N-methyl-D-aspartate (NMDA) receptors, opioid receptors, monoaminergic receptors, muscarinic receptors and voltage sensitive Ca ion channels. Unlike other general anaesthetic agents, ketamine does not interact with GABA receptors. Drug type: Approved. Small Molecule. Drug category: Analgesics. Anesthetics, Dissociative. Excitatory Amino Acid Antagonists. General Anesthetics |
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| has characteristic | ||
| label |
Ketamine |
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| prefixIRI |
NIFSTD:DB01221 |
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| prefLabel |
Ketamine |
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| synonym |
(S)-Ketamine Esketamine Ketalar SV CI 581 base Ketanest Ketamine HCL (S)-(-)-Ketamine Ketalar l-Ketamine CLSTA 20 (-)-Ketamine Ketamine Base Ketalar base Ketaject Ketolar |
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| subClassOf |