loading...| Preferred Name |
Epinephrine |
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| Synonyms |
Epipen Auto-Injector Myosthenine Vasoconstrictine Adrenapax Intranefrin Suprarenin L-Adrenaline Asthma Meter Mist Brevirenin Adrenutol Norartrinal Takamine Soladren Exadrin Tolansin Racepinefrine Metanephrin Antiasthmatique Nor-Epirenan Sympathin E Supranephrine Adrenodis Tolhart Supracapsulin L-Adrenalin L-Epinephine Chelafrin Adrenohorma Epipen Asthmahaler Mist Duranest Epi EZ Pen Jr Glaucon Epinephran Adrenaline Surenine Renoform Renostyptin Aktamin Medihaler-Epi Adrenan Renaglandulin Levonor Glaucosan Hyporenin Epinephrinum (INN-Latin) ADR Adrenaline Levorenen Sindrenina D-Adrenaline Twinject Adrin Renagladin L-Epinephrine Adrenalin Vasoton Renaleptine Adrenalin Chloride Haemostatin Adrine Glauposine Supranephrane L-Adrenaline Base Asthmanefrin Astminhal Epirenamine Balmadren Nephron Epirenin Sus-Phrine Scurenaline Levoadrenaline Isoptoepinal Adrenor Suprarenaline Susphrine Surrenine Auto-Injector Asthma-Nefrin Hektalin Renaglandin Renalina Eppy Bronkaid Mist Esphygmogenina Epipen EZ Pen Hemisine Styptirenal Epitrate L-Epirenamine Stryptirenal Adrenamine Adrenalinum Levorenine Tolax Biorenine Mytrate Bronkaid Suspension Mist Drenamist Adrenalina Nieraline Epinefrina (INN-Spanish) Paranephrin Adrenatrate adrenaline Bronkaid Levoepinephrine Nephridine ADROP Mucidrina Suprel Vaponefrin Epiglaufrin IOP Adrenasol Racepinefrina (inn-spanish) Renostypticin D-Epifrin Renostypricin Glycirenan Micronefrin Adnephrine D-Epinephrine Septocaine Supranefran Dylephrin Hemostatin Epirenan Hypernephrin Bernarenin Simplene Adrenalin-Medihaler Adrenine Epinephrine Bitartrate Corisol Supradin Epinefrin (Czech) Levorenin Hemostasin Epifrin Lidocaton Vasotonin Tonogen Racepinephrine Iontocaine Citanest Forte Vasodrine Epipen Jr Tokamina Kidoline Adrenosan Bosmin Supranol Sphygmogenin Haemostasin Adrenal Racepinefrinum (inn-latin) Takamina Asmatane Mist Lyophrin Astmahalin Primatene Mist Ana-Guard Sympathin I Tolcil |
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| Definitions |
The active sympathomimetic hormone from the adrenal medulla in most species. It stimulates both the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels. It is used in asthma and cardiac failure and to delay absorption of local anesthetics. (PubChem) Pharmacology: Epinephrine is indicated for intravenous injection in treatment of acute hypersensitivity, treatment of acute asthmatic attacks to relieve bronchospasm, and treatment and prophylaxis of cardiac arrest and attacks of transitory atrioventricular heart block with syncopal seizures (Stokes-Adams Syndrome). The actions of epinephrine resemble the effects of stimulation of adrenergic nerves. To a variable degree it acts on both alpha and beta receptor sites of sympathetic effector cells. Its most prominent actions are on the beta receptors of the heart, vascular and other smooth muscle. When given by rapid intravenous injection, it produces a rapid rise in blood pressure, mainly systolic, by (1) direct stimulation of cardiac muscle which increases the strength of ventricular contraction, (2) increasing the heart rate and (3) constriction of the arterioles in the skin, mucosa and splanchnic areas of the circulation. When given by slow intravenous injection, epinephrine usually produces only a moderate rise in systolic and a fall in diastolic pressure. Although some increase in pulse pressure occurs, there is usually no great elevation in mean blood pressure. Accordingly, the compensatory reflex mechanisms that come into play with a pronounced increase in blood pressure do not antagonize the direct cardiac actions of epinephrine as much as with catecholamines that have a predominant action on alpha receptors. Mechanism of action: Epinephrine works via the stimulation of alpha and beta-1 adrenergic receptors, and a moderate activity at beta-2 adrenergic receptors. Drug type: Approved. Small Molecule. Drug category: Adrenergic Agonists. Adrenergic alpha-Agonists. Adrenergic beta-Agonists. Bronchodilator Agents. Mydriatics. Sympathomimetics. Vasoconstrictor Agents |
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| ID |
http://uri.neuinfo.org/nif/nifstd/DB00668 |
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| createdDate |
2007-09-19 |
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| definition |
The active sympathomimetic hormone from the adrenal medulla in most species. It stimulates both the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels. It is used in asthma and cardiac failure and to delay absorption of local anesthetics. (PubChem) Pharmacology: Epinephrine is indicated for intravenous injection in treatment of acute hypersensitivity, treatment of acute asthmatic attacks to relieve bronchospasm, and treatment and prophylaxis of cardiac arrest and attacks of transitory atrioventricular heart block with syncopal seizures (Stokes-Adams Syndrome). The actions of epinephrine resemble the effects of stimulation of adrenergic nerves. To a variable degree it acts on both alpha and beta receptor sites of sympathetic effector cells. Its most prominent actions are on the beta receptors of the heart, vascular and other smooth muscle. When given by rapid intravenous injection, it produces a rapid rise in blood pressure, mainly systolic, by (1) direct stimulation of cardiac muscle which increases the strength of ventricular contraction, (2) increasing the heart rate and (3) constriction of the arterioles in the skin, mucosa and splanchnic areas of the circulation. When given by slow intravenous injection, epinephrine usually produces only a moderate rise in systolic and a fall in diastolic pressure. Although some increase in pulse pressure occurs, there is usually no great elevation in mean blood pressure. Accordingly, the compensatory reflex mechanisms that come into play with a pronounced increase in blood pressure do not antagonize the direct cardiac actions of epinephrine as much as with catecholamines that have a predominant action on alpha receptors. Mechanism of action: Epinephrine works via the stimulation of alpha and beta-1 adrenergic receptors, and a moderate activity at beta-2 adrenergic receptors. Drug type: Approved. Small Molecule. Drug category: Adrenergic Agonists. Adrenergic alpha-Agonists. Adrenergic beta-Agonists. Bronchodilator Agents. Mydriatics. Sympathomimetics. Vasoconstrictor Agents |
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| label |
Epinephrine |
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| modifiedDate |
April 22, 2010 |
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| preferred label |
Epinephrine |
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| prefixIRI |
NIFSTD:DB00668 |
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| synonym |
Epipen Auto-Injector Myosthenine Vasoconstrictine Adrenapax Intranefrin Suprarenin L-Adrenaline Asthma Meter Mist Brevirenin Adrenutol Norartrinal Takamine Soladren Exadrin Tolansin Racepinefrine Metanephrin Antiasthmatique Nor-Epirenan Sympathin E Supranephrine Adrenodis Tolhart Supracapsulin L-Adrenalin L-Epinephine Chelafrin Adrenohorma Epipen Asthmahaler Mist Duranest Epi EZ Pen Jr Glaucon Epinephran Adrenaline Surenine Renoform Renostyptin Aktamin Medihaler-Epi Adrenan Renaglandulin Levonor Glaucosan Hyporenin Epinephrinum (INN-Latin) ADR Adrenaline Levorenen Sindrenina D-Adrenaline Twinject Adrin Renagladin L-Epinephrine Adrenalin Vasoton Renaleptine Adrenalin Chloride Haemostatin Adrine Glauposine Supranephrane L-Adrenaline Base Asthmanefrin Astminhal Epirenamine Balmadren Nephron Epirenin Sus-Phrine Scurenaline Levoadrenaline Isoptoepinal Adrenor Suprarenaline Susphrine Surrenine Auto-Injector Asthma-Nefrin Hektalin Renaglandin Renalina Eppy Bronkaid Mist Esphygmogenina Epipen EZ Pen Hemisine Styptirenal Epitrate L-Epirenamine Stryptirenal Adrenamine Adrenalinum Levorenine Tolax Biorenine Mytrate Bronkaid Suspension Mist Drenamist Adrenalina Nieraline Epinefrina (INN-Spanish) Paranephrin Adrenatrate adrenaline Bronkaid Levoepinephrine Nephridine ADROP Mucidrina Suprel Vaponefrin Epiglaufrin IOP Adrenasol Racepinefrina (inn-spanish) Renostypticin D-Epifrin Renostypricin Glycirenan Micronefrin Adnephrine D-Epinephrine Septocaine Supranefran Dylephrin Hemostatin Epirenan Hypernephrin Bernarenin Simplene Adrenalin-Medihaler Adrenine Epinephrine Bitartrate Corisol Supradin Epinefrin (Czech) Levorenin Hemostasin Epifrin Lidocaton Vasotonin Tonogen Racepinephrine Iontocaine Citanest Forte Vasodrine Epipen Jr Tokamina Kidoline Adrenosan Bosmin Supranol Sphygmogenin Haemostasin Adrenal Racepinefrinum (inn-latin) Takamina Asmatane Mist Lyophrin Astmahalin Primatene Mist Ana-Guard Sympathin I Tolcil |
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| subClassOf |