Preferred Name

sulindac

Synonyms

(Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid

sulindaco

cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid

{(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid

cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid

Sulindac

Sulindacum

sulindac

Clinoril

Definitions

A monocarboxylic acid that is 1-benzylidene-1H-indene which is substituted at positions 2, 3, and 5 by methyl, carboxymethyl, and fluorine respectively, and in which the phenyl group of the benzylidene moiety is substituted at the para position by a methylsulfinyl group. It is a prodrug for the corresponding sulfide, a non-steroidal anti-inflammatory drug, used particularly in the treatment of acute and chronic inflammatory conditions.

ID

http://purl.obolibrary.org/obo/CHEBI_9352

charge

0

database_cross_reference

KEGG:D00120

Drug_Central:2534

HMDB:HMDB0014743

PMID:19884509

Patent:DE2039426

PMID:12406542

PMID:11569947

KEGG:C01531

Beilstein:2951842

PDBeChem:SUZ

PMID:15123337

Reaxys:2951842

CAS:38194-50-2

DrugBank:DB00605

PMID:23804703

Patent:US3654349

Wikipedia:Sulindac

PMID:11927004

PMID:15020200

PMID:23689354

formula

C20H17FO3S

has functional parent

http://purl.obolibrary.org/obo/CHEBI_15366

has role

http://purl.obolibrary.org/obo/CHEBI_66993

http://purl.obolibrary.org/obo/CHEBI_50266

http://purl.obolibrary.org/obo/CHEBI_35610

http://purl.obolibrary.org/obo/CHEBI_35544

http://purl.obolibrary.org/obo/CHEBI_35475

http://purl.obolibrary.org/obo/CHEBI_35493

http://purl.obolibrary.org/obo/CHEBI_35481

http://purl.obolibrary.org/obo/CHEBI_68495

has_exact_synonym

{(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid

Sulindac

has_obo_namespace

chebi_ontology

has_related_synonym

(Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid

sulindaco

cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid

cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid

Sulindacum

sulindac

Clinoril

id

CHEBI:9352

in_subset

http://purl.obolibrary.org/obo/chebi#3_STAR

inchi

InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-

inchikey

MLKXDPUZXIRXEP-MFOYZWKCSA-N

label

sulindac

mass

356.41158

monoisotopicmass

356.088

notation

CHEBI:9352

prefLabel

sulindac

smiles

CC1=C(CC(O)=O)c2cc(F)ccc2C1=C/c1ccc(cc1)S(C)=O

textual definition

A monocarboxylic acid that is 1-benzylidene-1H-indene which is substituted at positions 2, 3, and 5 by methyl, carboxymethyl, and fluorine respectively, and in which the phenyl group of the benzylidene moiety is substituted at the para position by a methylsulfinyl group. It is a prodrug for the corresponding sulfide, a non-steroidal anti-inflammatory drug, used particularly in the treatment of acute and chronic inflammatory conditions.

subClassOf

http://purl.obolibrary.org/obo/CHEBI_25384

http://purl.obolibrary.org/obo/CHEBI_22063

http://purl.obolibrary.org/obo/CHEBI_37143

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http://phenomebrowser.net/ontologies/mesh/mesh.owl#D013467 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/89505005 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146307 NDFRT LOOM
http://www.co-ode.org/ontologies/galen#Sulindac GALEN LOOM
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http://scai.fraunhofer.de/AlzheimerOntology#sulindac ADO LOOM
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http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C850 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C850 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C850 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C850 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C850 NCIT LOOM
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http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.847.486.875 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9352 EFO LOOM
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http://purl.obolibrary.org/obo/CHEBI_9352 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 EFO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9352 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 EFO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9352 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 NBO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9352 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 DINTO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9352 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 EFO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9352 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9352 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9352 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 CHEBI SAME_URI
http://d-nb.info/gnd/4358401-9 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/RXNORM/10237 RXNORM LOOM
http://id.loc.gov/authorities/subjects/sh85130323 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387513000 SNOMEDCT LOOM
http://purl.jp/bio/4/id/200906008974470052 IOBC LOOM
http://purl.jp/bio/4/id/200906008974470052 IOBC LOOM
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http://www.drugbank.ca/drugs/DB00605 FTC LOOM
http://purl.bioontology.org/ontology/SNMI/C-60440 SNMI LOOM
http://purl.bioontology.org/ontology/UATC/M01AB02 ATC LOOM