loading...| Preferred Name |
Methylphenidate |
|
| Synonyms |
rac-methyl (2R)-phenyl[(2R)-piperidin-2-yl]acetate methylphenidatum rac-threo-methyl alpha-phenyl-alpha-(2-piperidyl)acetate dl-threo-methylphenidate rac-threo-alpha-phenyl-2-piperidineacetic acid methyl ester methylphenidate methyl rac-threo-alpha-phenyl-alpha-2-piperidinylacetate Daytrana metilfenidato methyl rac-threo-phenidylacetate threo-(+-)-methylphenidate methylphenidan Ritalin Methylin ER hydrochloride Centedrin Methylin Metilfenidat hydrochloride Ritalin hydrochloride Metadate Plimasine Methypatch Ritalin-SR Methyl phenidyl acetate Metadate CD Methylphenidan d-methylphenidate HCl Phenidylate PMS-Methylphenidate Ritalin SR Methylphenidate hydrochloride Ritaline Metilfenidato (INN-Spanish) Centedein Riphenidate 4311/B Ciba Methylphenidylacetate Ritcher Works Centedrine Concerta Methylphen Methylofenidan Focalin Ritalin LA Centredin Methylphenidate HCl Metilfenidato (Italian) Focalin XR Methylphenidatum (INN-Latin) Metadate ER Calocain Meridil |
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| Definitions |
A central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine. (PubChem) Pharmacology: Methylphenidate is a central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine. Mechanism of action: Methylphenidate blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins. Methylphenidate acts at the brain stem arousal system and the cerebral cortex and causes increased sympathomimetic activity in the central nervous system. Alteration of serotonergic pathways via changes in dopamine transport may result. Drug type: Approved. Investigational. Small Molecule. Drug category: Adrenergic Agents. Adrenergic Uptake Inhibitors. Central Nervous System Stimulants. Dopamine Uptake Inhibitors. Sympathomimetics A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_6887 |
|
| charge |
0 |
|
| createdDate |
March 5, 2010 |
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| database_cross_reference |
HMDB:HMDB0014566 PMID:11862378 KEGG:C07196 PMID:25449360 CAS:20748-11-2 PMID:18978488 Patent:US2507631 PMID:23104969 KEGG:D04999 PMID:11160455 CAS:113-45-1 PMID:17201613 PMID:22098932 Reaxys:200061 PMID:16953648 PMID:23813595 PMID:25433180 PMID:18670250 Patent:US2957880 PMID:23975034 PMID:25553710 DrugBank:DB00422 Beilstein:200061 Wikipedia:Methylphenidate PMID:10786896 |
|
| definition |
A central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine. (PubChem) Pharmacology: Methylphenidate is a central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine. Mechanism of action: Methylphenidate blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins. Methylphenidate acts at the brain stem arousal system and the cerebral cortex and causes increased sympathomimetic activity in the central nervous system. Alteration of serotonergic pathways via changes in dopamine transport may result. Drug type: Approved. Investigational. Small Molecule. Drug category: Adrenergic Agents. Adrenergic Uptake Inhibitors. Central Nervous System Stimulants. Dopamine Uptake Inhibitors. Sympathomimetics |
|
| formula |
C14H19NO2 |
|
| has characteristic | ||
| has exact synonym |
rac-methyl (2R)-phenyl[(2R)-piperidin-2-yl]acetate |
|
| has part | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_35337 http://purl.obolibrary.org/obo/CHEBI_51039 http://purl.obolibrary.org/obo/CHEBI_35471 |
|
| has_obo_namespace |
chebi_ontology |
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| has_related_synonym |
methylphenidatum rac-threo-methyl alpha-phenyl-alpha-(2-piperidyl)acetate dl-threo-methylphenidate rac-threo-alpha-phenyl-2-piperidineacetic acid methyl ester methylphenidate methyl rac-threo-alpha-phenyl-alpha-2-piperidinylacetate Daytrana metilfenidato methyl rac-threo-phenidylacetate threo-(+-)-methylphenidate methylphenidan |
|
| hasExternalSource |
DB00422 |
|
| id |
CHEBI:6887 |
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| in_subset | ||
| is conjugate base of | ||
| label |
methylphenidate Methylphenidate |
|
| mass |
233.307 |
|
| modifiedDate |
May 21, 2010 |
|
| monoisotopicmass |
233.14158 |
|
| notation |
CHEBI:6887 |
|
| prefLabel |
Methylphenidate |
|
| synonym |
Ritalin Methylin ER hydrochloride Centedrin Methylin Metilfenidat hydrochloride Ritalin hydrochloride Metadate Plimasine Methypatch Ritalin-SR Methyl phenidyl acetate Metadate CD Methylphenidan d-methylphenidate HCl Phenidylate PMS-Methylphenidate Ritalin SR Methylphenidate hydrochloride Ritaline Metilfenidato (INN-Spanish) Centedein Riphenidate 4311/B Ciba Methylphenidylacetate Ritcher Works Centedrine Concerta Methylphen Methylofenidan Focalin Ritalin LA Centredin Methylphenidate HCl Metilfenidato (Italian) Focalin XR Methylphenidatum (INN-Latin) Metadate ER Calocain Meridil |
|
| subClassOf |