Preferred Name

Chlordiazepoxide

Synonyms

Librelease

Librium

Mesural

CDP

Methaminodiazepoxide

Chlordiazachel

Tropium

Chlordiazepoxide Base

Helogaphen

Menrium

Limbitrol Ds

Lygen

Apo-Chlordiazepoxide

Clordiazepossido

Mildmen

Psicosan

Kalmocaps

Napton

7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepin-4-oxide

Librax

Napoton

Ifibrium

Chlordiazepoxid

Chlordiazepoxide Hcl

Chloridazepoxide

Clopoxide

Elenium

methaminodiazepoxide

chlordiazepoxidum

Viopsicol

Risolid

chlordiazepoxide

Libritabs

Multum

Chloradiazepoxide

chlordiazepoxide base

Decacil

Chlorodiazepoxide

Librinin

Chloridiazepide

Chloridiazepoxide

Radepur

7-chloro-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-amine 4-oxide

Abboxide

Silibrin

Limbitrol

A-Poxide

clopoxide

Contol

Novo-Poxide

Chlozepid

Chlordiazepoxidum

Definitions

A benzodiazepine that is 3H-1,4-benzodiazepine 4-oxide substituted by a chloro group at position 7, a phenyl group at position 5 and a methylamino group at position 2. An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. (PubChem) Pharmacology: Chlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The precise mechanism of action is not known. The drug blocks EEG arousal from stimulation of the brain stem reticular formation. The drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. Hostile monkeys were made tame by oral drug doses which did not cause sedation. Chlordiazepoxide revealed a "taming" action with the elimination of fear and aggression. The taming effect of chlordiazepoxide was further demonstrated in rats made vicious by lesions in the septal area of the brain. The drug dosage which effectively blocked the vicious reaction was well below the dose which caused sedation in these animals. Mechanism of action: Chlordiazepoxide binds to stereospecific benzodiazepine (BZD) binding sites on GABA (A) receptor complexes at several sites within the central nervous system, including the limbic system and reticular formation. BZDs enhance GABA-mediated chloride influx through GABA receptor channels, causing membrane hyperpolarization. The net neuro-inhibitory effects result in the observed sedative, hypnotic, anxiolytic, and muscle relaxant properties. Drug type: Approved. Illicit. Small Molecule. Drug category: Adjuvants, Anesthesia. Anti-anxiety Agents. Benzodiazepines. GABA Modulators. Hypnotics and Sedatives Street names: Balance, CD 2, CDO, Control, Eden

ID

http://purl.obolibrary.org/obo/CHEBI_3611

comment

Street names: Balance, CD 2, CDO, Control, Eden

bearer of

http://uri.neuinfo.org/nif/nifstd/nlx_chem_090801

charge

0

createdDate

March 5, 2010

database_cross_reference

Reaxys:550356

PMID:19643124

CAS:58-25-3

KEGG:D00267

DrugBank:DB00475

Patent:US3122474

Drug_Central:594

Patent:MY6500040

PMID:9632243

Beilstein:550356

Wikipedia:Chlordiazepoxide

PMID:17049372

HMDB:HMDB0014618

Patent:US2893992

definition

An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. (PubChem) Pharmacology: Chlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The precise mechanism of action is not known. The drug blocks EEG arousal from stimulation of the brain stem reticular formation. The drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. Hostile monkeys were made tame by oral drug doses which did not cause sedation. Chlordiazepoxide revealed a "taming" action with the elimination of fear and aggression. The taming effect of chlordiazepoxide was further demonstrated in rats made vicious by lesions in the septal area of the brain. The drug dosage which effectively blocked the vicious reaction was well below the dose which caused sedation in these animals. Mechanism of action: Chlordiazepoxide binds to stereospecific benzodiazepine (BZD) binding sites on GABA (A) receptor complexes at several sites within the central nervous system, including the limbic system and reticular formation. BZDs enhance GABA-mediated chloride influx through GABA receptor channels, causing membrane hyperpolarization. The net neuro-inhibitory effects result in the observed sedative, hypnotic, anxiolytic, and muscle relaxant properties. Drug type: Approved. Illicit. Small Molecule. Drug category: Adjuvants, Anesthesia. Anti-anxiety Agents. Benzodiazepines. GABA Modulators. Hypnotics and Sedatives

formula

C16H14ClN3O

has role

http://purl.obolibrary.org/obo/CHEBI_35474

http://purl.obolibrary.org/obo/CHEBI_60807

http://purl.obolibrary.org/obo/CHEBI_35717

has_exact_synonym

7-chloro-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-amine 4-oxide

has_obo_namespace

chebi_ontology

has_related_synonym

CDP

Tropium

Helogaphen

7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepin-4-oxide

methaminodiazepoxide

chlordiazepoxidum

Risolid

chlordiazepoxide

Libritabs

Multum

chlordiazepoxide base

Silibrin

clopoxide

hasExternalSource

DB00475

hasStreetName

CD 2

Control

Eden

CDO

Balance

id

CHEBI:3611

in_subset

http://purl.obolibrary.org/obo/chebi#3_STAR

inchi

InChI=1S/C16H14ClN3O/c1-18-15-10-20(21)16(11-5-3-2-4-6-11)13-9-12(17)7-8-14(13)19-15/h2-9H,10H2,1H3,(H,18,19)

inchikey

ANTSCNMPPGJYLG-UHFFFAOYSA-N

label

Chlordiazepoxide

chlordiazepoxide

mass

299.75500

modifiedDate

June 30, 2010

monoisotopicmass

299.083

notation

CHEBI:3611

prefixIRI

CHEBI:CHEBI_3611

prefLabel

Chlordiazepoxide

smiles

CNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=N(=O)C1

synonym

Librelease

Librium

Mesural

Methaminodiazepoxide

Chlordiazachel

Chlordiazepoxide Base

Menrium

Limbitrol Ds

Lygen

Apo-Chlordiazepoxide

Clordiazepossido

Mildmen

Psicosan

Kalmocaps

Napton

Librax

Napoton

Ifibrium

Chlordiazepoxid

Chlordiazepoxide Hcl

Chloridazepoxide

Clopoxide

Elenium

Viopsicol

Chloradiazepoxide

Decacil

Chlorodiazepoxide

Librinin

Chloridiazepide

Chloridiazepoxide

Radepur

Abboxide

Limbitrol

A-Poxide

Contol

Novo-Poxide

Chlozepid

Chlordiazepoxidum

textual definition

A benzodiazepine that is 3H-1,4-benzodiazepine 4-oxide substituted by a chloro group at position 7, a phenyl group at position 5 and a methylamino group at position 2.

subClassOf

http://purl.obolibrary.org/obo/CHEBI_36683

http://purl.obolibrary.org/obo/CHEBI_22720

http://purl.obolibrary.org/obo/CHEBI_50995

http://purl.obolibrary.org/obo/CHEBI_35580

http://uri.neuinfo.org/nif/nifstd/nlx_chem_1003011

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