loading...| Preferred Name |
Chlordiazepoxide |
|
| Synonyms |
7-chloro-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-amine 4-oxide Helogaphen clopoxide Multum Silibrin CDP methaminodiazepoxide Tropium 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepin-4-oxide chlordiazepoxidum Libritabs chlordiazepoxide chlordiazepoxide base Risolid Novo-Poxide Menrium Radepur Apo-Chlordiazepoxide Clopoxide Clordiazepossido Chlordiazepoxide Hcl Librinin Chlordiazepoxidum Contol Napoton Limbitrol Psicosan A-Poxide Ifibrium Viopsicol Decacil Napton Chlordiazachel Librax Chloridazepoxide Mildmen Methaminodiazepoxide Abboxide Kalmocaps Chlozepid Limbitrol Ds Chloradiazepoxide Chlordiazepoxide Base Librelease Elenium Chloridiazepoxide Librium Chlordiazepoxid Mesural Chloridiazepide Chlorodiazepoxide Lygen |
|
| Definitions |
An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. (PubChem) Pharmacology: Chlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The precise mechanism of action is not known. The drug blocks EEG arousal from stimulation of the brain stem reticular formation. The drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. Hostile monkeys were made tame by oral drug doses which did not cause sedation. Chlordiazepoxide revealed a "taming" action with the elimination of fear and aggression. The taming effect of chlordiazepoxide was further demonstrated in rats made vicious by lesions in the septal area of the brain. The drug dosage which effectively blocked the vicious reaction was well below the dose which caused sedation in these animals. Mechanism of action: Chlordiazepoxide binds to stereospecific benzodiazepine (BZD) binding sites on GABA (A) receptor complexes at several sites within the central nervous system, including the limbic system and reticular formation. BZDs enhance GABA-mediated chloride influx through GABA receptor channels, causing membrane hyperpolarization. The net neuro-inhibitory effects result in the observed sedative, hypnotic, anxiolytic, and muscle relaxant properties. Drug type: Approved. Illicit. Small Molecule. Drug category: Adjuvants, Anesthesia. Anti-anxiety Agents. Benzodiazepines. GABA Modulators. Hypnotics and Sedatives Street names: Balance, CD 2, CDO, Control, Eden A benzodiazepine that is 3H-1,4-benzodiazepine 4-oxide substituted by a chloro group at position 7, a phenyl group at position 5 and a methylamino group at position 2. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_3611 |
|
| comment |
Street names: Balance, CD 2, CDO, Control, Eden |
|
| charge |
0 |
|
| createdDate |
March 5, 2010 |
|
| database_cross_reference |
CAS:58-25-3 Patent:MY6500040 Patent:US3122474 DrugBank:DB00475 Reaxys:550356 Beilstein:550356 PMID:19643124 Patent:US2893992 PMID:9632243 Wikipedia:Chlordiazepoxide KEGG:D00267 PMID:17049372 Drug_Central:594 HMDB:HMDB0014618 |
|
| definition |
An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. (PubChem) Pharmacology: Chlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The precise mechanism of action is not known. The drug blocks EEG arousal from stimulation of the brain stem reticular formation. The drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. Hostile monkeys were made tame by oral drug doses which did not cause sedation. Chlordiazepoxide revealed a "taming" action with the elimination of fear and aggression. The taming effect of chlordiazepoxide was further demonstrated in rats made vicious by lesions in the septal area of the brain. The drug dosage which effectively blocked the vicious reaction was well below the dose which caused sedation in these animals. Mechanism of action: Chlordiazepoxide binds to stereospecific benzodiazepine (BZD) binding sites on GABA (A) receptor complexes at several sites within the central nervous system, including the limbic system and reticular formation. BZDs enhance GABA-mediated chloride influx through GABA receptor channels, causing membrane hyperpolarization. The net neuro-inhibitory effects result in the observed sedative, hypnotic, anxiolytic, and muscle relaxant properties. Drug type: Approved. Illicit. Small Molecule. Drug category: Adjuvants, Anesthesia. Anti-anxiety Agents. Benzodiazepines. GABA Modulators. Hypnotics and Sedatives |
|
| formula |
C16H14ClN3O |
|
| has characteristic | ||
| has exact synonym |
7-chloro-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-amine 4-oxide |
|
| has role |
http://purl.obolibrary.org/obo/CHEBI_35474 |
|
| has_obo_namespace |
chebi_ontology |
|
| has_related_synonym |
Helogaphen clopoxide Multum Silibrin CDP methaminodiazepoxide Tropium 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepin-4-oxide chlordiazepoxidum Libritabs chlordiazepoxide chlordiazepoxide base Risolid |
|
| hasExternalSource |
DB00475 |
|
| hasStreetName |
CD 2 CDO Balance Eden Control |
|
| id |
CHEBI:3611 |
|
| in_subset | ||
| inchi |
InChI=1S/C16H14ClN3O/c1-18-15-10-20(21)16(11-5-3-2-4-6-11)13-9-12(17)7-8-14(13)19-15/h2-9H,10H2,1H3,(H,18,19) |
|
| inchikey |
ANTSCNMPPGJYLG-UHFFFAOYSA-N |
|
| label |
Chlordiazepoxide chlordiazepoxide |
|
| mass |
299.75500 |
|
| modifiedDate |
June 30, 2010 |
|
| monoisotopicmass |
299.08254 |
|
| notation |
CHEBI:3611 |
|
| prefLabel |
Chlordiazepoxide |
|
| smiles |
CNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=N(=O)C1 |
|
| synonym |
Novo-Poxide Menrium Radepur Apo-Chlordiazepoxide Clopoxide Clordiazepossido Chlordiazepoxide Hcl Librinin Chlordiazepoxidum Contol Napoton Limbitrol Psicosan A-Poxide Ifibrium Viopsicol Decacil Napton Chlordiazachel Librax Chloridazepoxide Mildmen Methaminodiazepoxide Abboxide Kalmocaps Chlozepid Limbitrol Ds Chloradiazepoxide Chlordiazepoxide Base Librelease Elenium Chloridiazepoxide Librium Chlordiazepoxid Mesural Chloridiazepide Chlorodiazepoxide Lygen |
|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_35580 http://purl.obolibrary.org/obo/CHEBI_50995 http://purl.obolibrary.org/obo/CHEBI_36683 |