Preferred Name |
amifostine |
|
Synonyms |
Amifostine S-{2-[(3-aminopropyl)amino]ethyl} dihydrogen thiophosphate amifostina amifostine amifostinum Ethyol |
|
Definitions |
An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy. |
|
ID |
http://purl.obolibrary.org/obo/CHEBI_2636 |
|
charge |
0 |
|
database_cross_reference |
PMID:15875769 PMID:22878481 PMID:22885239 PMID:11201306 PMID:21347716 PMID:22844290 PMID:22440042 Beilstein:2088122 PMID:22402174 Wikipedia:Amifostine PMID:12499421 PMID:23401928 PMID:17602063 Drug_Central:156 PMID:23040218 PMID:12433814 PMID:15698860 PMID:8612469 PMID:12005544 PMID:12751907 KEGG:C06819 PMID:8683243 PMID:21646919 PMID:10942928 Patent:US3892824 PMID:10553165 PMID:12561384 LINCS:LSM-4721 PMID:23092832 PMID:22456378 PMID:11984063 PMID:14980067 Reaxys:2088122 PMID:11013273 DrugBank:DB01143 PMID:19712749 PMID:20334641 CAS:20537-88-6 PMID:23052919 PMID:22496587 PMID:18072151 PMID:22267539 PMID:16465691 HMDB:HMDB0015274 PMID:22989457 PMID:22643562 PMID:18549666 PMID:15380592 |
|
definition |
An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy. |
|
formula |
C5H15N2O3PS |
|
has exact synonym |
Amifostine S-{2-[(3-aminopropyl)amino]ethyl} dihydrogen thiophosphate |
|
has functional parent | ||
has role |
http://purl.obolibrary.org/obo/CHEBI_22586 |
|
has_obo_namespace |
chebi_ontology |
|
has_related_synonym |
amifostina amifostine amifostinum Ethyol |
|
id |
CHEBI:2636 |
|
in_subset | ||
inchi |
InChI=1S/C5H15N2O3PS/c6-2-1-3-7-4-5-12-11(8,9)10/h7H,1-6H2,(H2,8,9,10) |
|
inchikey |
JKOQGQFVAUAYPM-UHFFFAOYSA-N |
|
label |
amifostine |
|
mass |
214.22404 |
|
monoisotopicmass |
214.05410 |
|
notation |
CHEBI:2636 |
|
prefLabel |
amifostine |
|
smiles |
NCCCNCCSP(O)(O)=O |
|
subClassOf |