Preferred Name

dopamine

Synonyms

Dophamine

3,4-Dihydroxyphenethylamine

2-(3,4-Dihydroxyphenyl)ethylamine

Dopamine HCl

4-(2-aminoethyl)-1,2-benzenediol

3-Hydroxytyramine

2-(3,4-dihydroxyphenyl)ethylamine

Dopamin

Hydroxytyramin

4-(2-Aminoethyl)benzene-1,2-diol

Dopamine

Intropin

dopaminum

Revimine

4-(2-Aminoethyl)-1,2-benzenediol

4-(2-aminoethyl)catechol

Deoxyepinephrine

dopamina

dopamine

4-(2-aminoethyl)benzene-1,2-diol

4-(2-aminoethyl)pyrocatechol

Oxytyramine

Definitions

Catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group. One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. (PubChem) Pharmacology: Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings. Mechanism of action: Dopamine is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings. Drug type: Approved. Small Molecule. Drug category: Cardiotonic Agents. Dopamine Agents. Sympathomimetic. Sympathomimetics

ID

http://purl.obolibrary.org/obo/CHEBI_18243

abbrev

DA

bearer of

http://uri.neuinfo.org/nif/nifstd/nlx_mol_20090515

charge

0

database_cross_reference

KNApSAcK:C00001408

PMID:9422813

LINCS:LSM-4630

MetaCyc:DOPAMINE

KEGG:D07870

Reaxys:1072822

PMID:10629745

KEGG:C03758

Drug_Central:947

HMDB:HMDB0000073

CAS:51-61-6

PMID:11149432

DrugBank:DB00988

Wikipedia:Dopamine

definition

One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. (PubChem) Pharmacology: Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings. Mechanism of action: Dopamine is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings. Drug type: Approved. Small Molecule. Drug category: Cardiotonic Agents. Dopamine Agents. Sympathomimetic. Sympathomimetics

formula

C8H11NO2

has role

http://purl.obolibrary.org/obo/CHEBI_48560

http://purl.obolibrary.org/obo/CHEBI_75771

http://purl.obolibrary.org/obo/CHEBI_35522

http://purl.obolibrary.org/obo/CHEBI_35524

http://purl.obolibrary.org/obo/CHEBI_77746

http://purl.obolibrary.org/obo/CHEBI_76971

http://purl.obolibrary.org/obo/CHEBI_38147

has_alternative_id

CHEBI:11695

CHEBI:23886

CHEBI:43686

CHEBI:11930

CHEBI:1764

CHEBI:14203

has_exact_synonym

Dopamine

4-(2-aminoethyl)benzene-1,2-diol

has_obo_namespace

chebi_ontology

has_related_synonym

3,4-Dihydroxyphenethylamine

2-(3,4-Dihydroxyphenyl)ethylamine

4-(2-aminoethyl)-1,2-benzenediol

3-Hydroxytyramine

2-(3,4-dihydroxyphenyl)ethylamine

Hydroxytyramin

4-(2-Aminoethyl)benzene-1,2-diol

dopaminum

4-(2-Aminoethyl)-1,2-benzenediol

4-(2-aminoethyl)catechol

Deoxyepinephrine

dopamina

dopamine

4-(2-aminoethyl)pyrocatechol

hasCurationStatus

uncurated

id

CHEBI:18243

in_subset

http://purl.obolibrary.org/obo/chebi#3_STAR

inchi

InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2

inchikey

VYFYYTLLBUKUHU-UHFFFAOYSA-N

is conjugate base of

http://purl.obolibrary.org/obo/CHEBI_59905

label

dopamine

mass

153.17840

modifiedDate

April 12, 2010

monoisotopicmass

153.079

notation

CHEBI:18243

prefixIRI

CHEBI:CHEBI_18243

prefLabel

dopamine

smiles

NCCc1ccc(O)c(O)c1

synonym

Dophamine

Dopamine HCl

Dopamin

Intropin

Revimine

Oxytyramine

textual definition

Catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group.

umls_ID

C0013030

disjointWith

http://uri.neuinfo.org/nif/nifstd/sao185580330

http://uri.neuinfo.org/nif/nifstd/sao711465902

subClassOf

http://uri.neuinfo.org/nif/nifstd/sao1456045859

http://purl.obolibrary.org/obo/CHEBI_33567

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