loading...| Preferred Name |
dopamine |
|
| Synonyms |
4-(2-aminoethyl)benzene-1,2-diol Dopamine 2-(3,4-dihydroxyphenyl)ethylamine Deoxyepinephrine 4-(2-Aminoethyl)benzene-1,2-diol 3-Hydroxytyramine 4-(2-aminoethyl)pyrocatechol Hydroxytyramin 4-(2-Aminoethyl)-1,2-benzenediol dopaminum 2-(3,4-Dihydroxyphenyl)ethylamine 4-(2-aminoethyl)catechol dopamine 3,4-Dihydroxyphenethylamine dopamina 4-(2-aminoethyl)-1,2-benzenediol Dopamin Revimine Dopamine HCl Oxytyramine Intropin Dophamine |
|
| Definitions |
One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. (PubChem) Pharmacology: Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings. Mechanism of action: Dopamine is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings. Drug type: Approved. Small Molecule. Drug category: Cardiotonic Agents. Dopamine Agents. Sympathomimetic. Sympathomimetics Catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_18243 |
|
| abbrev |
DA |
|
| charge |
0 |
|
| database_cross_reference |
KNApSAcK:C00001408 KEGG:C03758 KEGG:D07870 MetaCyc:DOPAMINE Wikipedia:Dopamine PMID:11149432 HMDB:HMDB0000073 DrugBank:DB00988 Reaxys:1072822 LINCS:LSM-4630 CAS:51-61-6 PMID:9422813 Drug_Central:947 PMID:10629745 |
|
| definition |
One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. (PubChem) Pharmacology: Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings. Mechanism of action: Dopamine is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings. Drug type: Approved. Small Molecule. Drug category: Cardiotonic Agents. Dopamine Agents. Sympathomimetic. Sympathomimetics |
|
| formula |
C8H11NO2 |
|
| has characteristic | ||
| has exact synonym |
4-(2-aminoethyl)benzene-1,2-diol Dopamine |
|
| has role |
http://purl.obolibrary.org/obo/CHEBI_48560 http://purl.obolibrary.org/obo/CHEBI_35524 http://purl.obolibrary.org/obo/CHEBI_35522 http://purl.obolibrary.org/obo/CHEBI_77746 http://purl.obolibrary.org/obo/CHEBI_75771 |
|
| has_alternative_id |
CHEBI:11930 CHEBI:43686 CHEBI:23886 CHEBI:11695 CHEBI:14203 CHEBI:1764 |
|
| has_obo_namespace |
chebi_ontology |
|
| has_related_synonym |
2-(3,4-dihydroxyphenyl)ethylamine Deoxyepinephrine 4-(2-Aminoethyl)benzene-1,2-diol 3-Hydroxytyramine 4-(2-aminoethyl)pyrocatechol Hydroxytyramin 4-(2-Aminoethyl)-1,2-benzenediol dopaminum 2-(3,4-Dihydroxyphenyl)ethylamine 4-(2-aminoethyl)catechol dopamine 3,4-Dihydroxyphenethylamine dopamina 4-(2-aminoethyl)-1,2-benzenediol |
|
| hasCurationStatus |
uncurated |
|
| id |
CHEBI:18243 |
|
| in_subset | ||
| inchi |
InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 |
|
| inchikey |
VYFYYTLLBUKUHU-UHFFFAOYSA-N |
|
| is conjugate base of | ||
| label |
dopamine |
|
| mass |
153.17840 |
|
| modifiedDate |
April 12, 2010 |
|
| monoisotopicmass |
153.07898 |
|
| notation |
CHEBI:18243 |
|
| prefLabel |
dopamine |
|
| smiles |
NCCc1ccc(O)c(O)c1 |
|
| synonym |
Dopamin Revimine Dopamine HCl Oxytyramine Intropin Dophamine |
|
| umls_ID |
C0013030 |
|
| disjointWith | ||
| subClassOf |