loading...| Preferred Name |
Amyotrophic Lateral Sclerosis |
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| Synonyms |
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| Definitions |
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts (MeSH). |
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| ID |
http://uri.neuinfo.org/nif/nifstd/birnlex_12566 |
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| acronym |
ALS |
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| createdDate |
2007-10-05 |
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| definingCitation |
Adams et al., Principles of Neurology, 6th ed, pp1089-94 |
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| definingCitationURI |
http://www.ninds.nih.gov/disorders/amyotrophiclateralsclerosis/amyotrophiclateralsclerosis.htm |
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| definition |
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts (MeSH). |
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| hasBirnlexCurator | ||
| hasCurationStatus | ||
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| label |
Amyotrophic Lateral Sclerosis |
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| MeshUid |
D000690 |
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| modifiedDate |
April 11, 2009 |
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| nifID |
_8.3_2.5.1 |
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| preferred label |
Amyotrophic Lateral Sclerosis |
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| synonym |
Gehrigs Disease Lou Gehrig Disease Lou Gehrig's Disease Gehrig's Disease Lou Gehrigs Disease |
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| subClassOf |