National Drug File - Reference Terminology - Methotrexate [Chemical/Ingredient] - Classes | NCBO BioPortal

National Drug File - Reference Terminology

Last uploaded: July 6, 2018

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Preferred Name	Methotrexate [Chemical/Ingredient]
Synonyms	Amethopterin Methotrexate
ID	http://purl.bioontology.org/ontology/NDFRT/N0000007370
altLabel	Amethopterin L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)- Methotrexate
Contraindicating class of	http://purl.bioontology.org/ontology/NDFRT/N0000147631 http://purl.bioontology.org/ontology/NDFRT/N0000148524 http://purl.bioontology.org/ontology/NDFRT/N0000160983 http://purl.bioontology.org/ontology/NDFRT/N0000182810 http://purl.bioontology.org/ontology/NDFRT/N0000160984
cui	C0025677
Ingredient of	http://purl.bioontology.org/ontology/NDFRT/N0000191121 http://purl.bioontology.org/ontology/NDFRT/N0000192402 http://purl.bioontology.org/ontology/NDFRT/N0000191118 http://purl.bioontology.org/ontology/NDFRT/N0000191120 http://purl.bioontology.org/ontology/NDFRT/N0000191123 http://purl.bioontology.org/ontology/NDFRT/N0000020733 http://purl.bioontology.org/ontology/NDFRT/N0000147916 http://purl.bioontology.org/ontology/NDFRT/N0000191127 http://purl.bioontology.org/ontology/NDFRT/N0000192530 http://purl.bioontology.org/ontology/NDFRT/N0000191125 http://purl.bioontology.org/ontology/NDFRT/N0000191126 http://purl.bioontology.org/ontology/NDFRT/N0000191122 http://purl.bioontology.org/ontology/NDFRT/N0000192716 http://purl.bioontology.org/ontology/NDFRT/N0000191640 http://purl.bioontology.org/ontology/NDFRT/N0000192403 http://purl.bioontology.org/ontology/NDFRT/N0000191124 http://purl.bioontology.org/ontology/NDFRT/N0000192529
MESH DEFINITION	An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
MESH DUI	D008727
MeSH name	Methotrexate
MESH UI	M0013595
NDFRT kind	INGREDIENT_KIND
notation	N0000007370
NUI	N0000007370
prefLabel	Methotrexate [Chemical/Ingredient]
tui	T109 T121
subClassOf	http://purl.bioontology.org/ontology/NDFRT/N0000007861

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Delete	Mapping To	Ontology	Source
	http://purl.bioontology.org/ontology/SNMI/C-78170	SNMI	CUI
	http://purl.bioontology.org/ontology/MESH/D008727	MESH	CUI
	http://purl.bioontology.org/ontology/ATC/L01BA01	ATC	CUI
	http://purl.bioontology.org/ontology/ATC/L04AX03	ATC	CUI
	http://purl.bioontology.org/ontology/SCTSPA/68887009	SCTSPA	CUI
	http://purl.bioontology.org/ontology/PDQ/CDR0000041719	PDQ	CUI
	http://purl.bioontology.org/ontology/RCD/h34..	RCD	CUI
	http://purl.bioontology.org/ontology/MSHFRE/D008727	MSHFRE	CUI
	http://purl.bioontology.org/ontology/VANDF/4019828	VANDF	CUI
	http://purl.bioontology.org/ontology/LNC/LP16198-1	LOINC	CUI
	http://purl.bioontology.org/ontology/CSP/1175-1202	CRISP	CUI
	http://purl.bioontology.org/ontology/SCTSPA/387381009	SCTSPA	CUI
	http://purl.bioontology.org/ontology/LNC/LA14339-8	LOINC	CUI
	http://purl.bioontology.org/ontology/NDDF/002644	NDDF	CUI
	http://purl.bioontology.org/ontology/SNOMEDCT/387381009	SNOMEDCT	CUI
	http://purl.bioontology.org/ontology/RXNORM/6851	RXNORM	CUI
	http://purl.bioontology.org/ontology/LNC/MTHU005020	LOINC	CUI
	http://purl.bioontology.org/ontology/SNOMEDCT/68887009	SNOMEDCT	CUI
	http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000007370	ODAE	LOOM