loading...| Preferred Name |
Lewy body disease |
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| Synonyms |
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| Definitions |
Lewy body disease is a neurological disease where cognitive deficits [memory, visual spatial, attention, orientation, executive function, functional] occur that represent a decline from previous levels of functioning resulting in dementia as well as visual hallucinations or fluctuations or REM sleep behavior disorder or Parkonsinism occur caused by neurodegeneration as a result of deposition of Lewy bodies in the cerebral cortex and limbic structures. A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, MUSCLE RIGIDITY, and other extrapyramidal signs. DELUSIONS and visual HALLUCINATIONS are relatively frequent in this condition. Histologic examination reveals LEWY BODIES in the CEREBRAL CORTEX and BRAIN STEM. SENILE PLAQUES and other pathologic features characteristic of ALZHEIMER DISEASE may also be present. |
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| ID |
http://purl.obolibrary.org/obo/ND_0000118 |
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| alternative term |
senile dementia of Lewy type dementia with Lewy bodies diffuse Lewy body disease Lewy body dementia cortical Lewy body disease DLB LBD |
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| definition |
Lewy body disease is a neurological disease where cognitive deficits [memory, visual spatial, attention, orientation, executive function, functional] occur that represent a decline from previous levels of functioning resulting in dementia as well as visual hallucinations or fluctuations or REM sleep behavior disorder or Parkonsinism occur caused by neurodegeneration as a result of deposition of Lewy bodies in the cerebral cortex and limbic structures. A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, MUSCLE RIGIDITY, and other extrapyramidal signs. DELUSIONS and visual HALLUCINATIONS are relatively frequent in this condition. Histologic examination reveals LEWY BODIES in the CEREBRAL CORTEX and BRAIN STEM. SENILE PLAQUES and other pathologic features characteristic of ALZHEIMER DISEASE may also be present. |
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| definition editor |
Alexander P. Cox |
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| definition source | ||
| hasDbXref |
http://ontology.neuinfo.org/NIF/Dysfunction/NIF-Dysfunction.owl#birnlex_12502 |
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| label |
Lewy body disease |
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| prefixIRI |
ND:0000118 |
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| prefLabel |
Lewy body disease |
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| subClassOf |