Preferred Name

alpha synucleinopathy

Synonyms
Definitions

def [proposed] is hypothetical Besides Parkinson's disease, the filamentous inclusions of two additional neurodegenerative diseases, namely, dementia with Lewy bodies and multiple system atrophy, have also been found to be made of alpha-synuclein. Recombinant alpha-synuclein has been shown to assemble into filaments with similar morphologies to those found in the human diseases and with a cross-beta fiber diffraction pattern. The new work has established the alpha-synucleinopathies as a major class of neurodegenerative disease. From: http://www.ncbi.nlm.nih.gov/pubmed/11193145 Alpha-synucleinopathy is a neurological disease ................. that results in the degeneration of populations of nerve cells that develop Lewy bodies and Lewy neurites as a result of filamentous inclusions made of the protein alpha-synuclein. *** NEEDS REVIEW *** [PROPOSED] initially affects the medulla oblongata and progresses to more rostral brain areas in a hierarchical sequence ("Braak hypothesis"). Predominant involvement of the amygdala is also described.

ID

http://purl.obolibrary.org/obo/ND_0000068

comment

def [proposed] is hypothetical

Besides Parkinson's disease, the filamentous inclusions of two additional neurodegenerative diseases, namely, dementia with Lewy bodies and multiple system atrophy, have also been found to be made of alpha-synuclein. Recombinant alpha-synuclein has been shown to assemble into filaments with similar morphologies to those found in the human diseases and with a cross-beta fiber diffraction pattern. The new work has established the alpha-synucleinopathies as a major class of neurodegenerative disease. From: http://www.ncbi.nlm.nih.gov/pubmed/11193145

alternative term

α-synucleinopathies

alpha-synucleinopathy

α-synucleinopathy

alpha-synucleinopathies

definition

Alpha-synucleinopathy is a neurological disease ................. that results in the degeneration of populations of nerve cells that develop Lewy bodies and Lewy neurites as a result of filamentous inclusions made of the protein alpha-synuclein. *** NEEDS REVIEW ***

[PROPOSED] initially affects the medulla oblongata and progresses to more rostral brain areas in a hierarchical sequence ("Braak hypothesis"). Predominant involvement of the amygdala is also described.

definition editor

Alexander P. Cox

definition source

http://www.ncbi.nlm.nih.gov/pubmed/18362284

label

alpha synucleinopathy

prefixIRI

ND:0000068

prefLabel

alpha synucleinopathy

subClassOf

http://purl.obolibrary.org/obo/ND_0000113

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