loading...| Preferred Name |
Acitretin |
|
| Synonyms |
Trimethylmethoxyphenyl-retinoic acid (All-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic Acid ACITRETIN Acitretin Etretin Neotigason Ro 10-1670 Ro-10-1670 Soriatane acitretin |
|
| Definitions |
An orally-active metabolite of the synthetic aromatic retinoic acid agent etretinate with potential antineoplastic, chemopreventive, anti-psoratic, and embryotoxic properties. Acitretin activates nuclear retinoic acid receptors (RAR), resulting in induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells. This agent may also inhibit tumor angiogenesis. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C985 |
|
| Accepted_Therapeutic_Use_For |
Psoriasis; cutaneous T-cell lymphoma |
|
| ALT_DEFINITION |
A substance that is used in the prevention of cancer and in the treatment of psoriasis. It belongs to the family of drugs called retinoids. |
|
| CAS_Registry |
55079-83-9 |
|
| CHEBI_ID |
CHEBI:50173 |
|
| Chemical_Formula |
C21H26O3 |
|
| code |
C985 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
FDA GDC |
|
| DEFINITION |
An orally-active metabolite of the synthetic aromatic retinoic acid agent etretinate with potential antineoplastic, chemopreventive, anti-psoratic, and embryotoxic properties. Acitretin activates nuclear retinoic acid receptors (RAR), resulting in induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells. This agent may also inhibit tumor angiogenesis. (NCI04) |
|
| FDA_UNII_Code |
LCH760E9T7 |
|
| FULL_SYN |
Trimethylmethoxyphenyl-retinoic acid (All-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic Acid ACITRETIN Acitretin Etretin Neotigason Ro 10-1670 Ro-10-1670 Soriatane acitretin |
|
| Is_Value_For_GDC_Property | ||
| label |
Acitretin |
|
| Legacy Concept Name |
Acitretin |
|
| Maps_To |
Acitretin |
|
| NCI_Drug_Dictionary_ID |
43244 |
|
| PDQ_Closed_Trial_Search_ID |
43244 |
|
| PDQ_Open_Trial_Search_ID |
43244 |
|
| Preferred_Name |
Acitretin |
|
| prefixIRI |
Thesaurus:C985 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0050559 |
|
| subClassOf |