National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

GLP-1 Mimetics
Synonyms

GLP-1 Mimetics

GLP-1 Receptor Agonist

GLP-1 Analogue

GLP-1 receptor agonist
Definitions

Any of the analogues of the endogenous gastrointestinal hormone glucagon-like peptide-1 (GLP-1) with antihyperglycemic activity. GLP-1 mimetics mimic the activity of GLP-1 and thereby stimulate glucose-dependent secretion of insulin from pancreatic beta cells, suppress glucagon secretion from alpha cells, increase insulin sensitivity and inhibit gastric emptying thereby slowing absorption of nutrients and creating a satiating effect. Altogether, this lowers blood glucose levels. GLP-1 is rapidly inactivated by the enzyme dipeptidyl peptidase-4 (DPP-4).
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98085
ALT_DEFINITION

Select medications in this class have been shown to improve ASCVD outcomes, drive weight loss, and lower glucose.
code

C98085
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191670

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191200

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191387

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191405
Contributing_Source

ACC/AHA
DEFINITION

Any of the analogues of the endogenous gastrointestinal hormone glucagon-like peptide-1 (GLP-1) with antihyperglycemic activity. GLP-1 mimetics mimic the activity of GLP-1 and thereby stimulate glucose-dependent secretion of insulin from pancreatic beta cells, suppress glucagon secretion from alpha cells, increase insulin sensitivity and inhibit gastric emptying thereby slowing absorption of nutrients and creating a satiating effect. Altogether, this lowers blood glucose levels. GLP-1 is rapidly inactivated by the enzyme dipeptidyl peptidase-4 (DPP-4).
FULL_SYN

GLP-1 Mimetics

GLP-1 Receptor Agonist

GLP-1 Analogue

GLP-1 receptor agonist
Has_ACC-AHA_SARS2_Authorized_Value

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17998

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49488

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49487
label

GLP-1 Mimetics
Preferred_Name

GLP-1 Mimetics
prefixIRI

Thesaurus:C98085
Semantic_Type

Chemical Viewed Functionally
UMLS_CUI

C3273809
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29711
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http://purl.obolibrary.org/obo/NCIT_C98085 BERO LOOM