National Cancer Institute Thesaurus

Last uploaded: July 29, 2019
Preferred Name

Non-nucleoside Reverse Transcriptase Inhibitor

Synonyms

NNRTI

Non-nucleoside Reverse Transcriptase Inhibitor

Definitions

A substance structurally unlike a nucleoside molecule that is capable of inhibiting the function of a reverse transcriptase. These compounds do not bind to the active site of the polymerase but in a less conserved pocket near the active site, causing a distortion in the shape of the active site and resulting in inhibition of enzymatic function, chain termination, and inhibition of viral replication.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97453

code

C97453

DEFINITION

A substance structurally unlike a nucleoside molecule that is capable of inhibiting the function of a reverse transcriptase. These compounds do not bind to the active site of the polymerase but in a less conserved pocket near the active site, causing a distortion in the shape of the active site and resulting in inhibition of enzymatic function, chain termination, and inhibition of viral replication.

FULL_SYN

NNRTI

Non-nucleoside Reverse Transcriptase Inhibitor

label

Non-nucleoside Reverse Transcriptase Inhibitor

Preferred_Name

Non-nucleoside Reverse Transcriptase Inhibitor

prefixIRI

ncit:C97453

Semantic_Type

Chemical Viewed Functionally

UMLS_CUI

C1373120

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1589

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Delete Mapping To Ontology Source
http://www.semanticweb.org/owner/ontologies/2014/6/Drug.owl#Non-NucleosideReverseTranscriptaseInhibitor HCODONONT LOOM
http://purl.jp/bio/4/id/200906024002293172 IOBC LOOM
http://purl.jp/bio/4/id/200906024002293172 IOBC LOOM
http://purl.jp/bio/4/id/200906024002293172 IOBC LOOM
http://scai.fraunhofer.de/HuPSON#SCAIVPH_00001108 HUPSON LOOM