Preferred Name |
Non-nucleoside Reverse Transcriptase Inhibitor |
|
Synonyms |
Non-nucleoside Reverse Transcriptase Inhibitor NNRTI |
|
Definitions |
A substance structurally unlike a nucleoside molecule that is capable of inhibiting the function of a reverse transcriptase. These compounds do not bind to the active site of the polymerase but in a less conserved pocket near the active site, causing a distortion in the shape of the active site and resulting in inhibition of enzymatic function, chain termination, and inhibition of viral replication. |
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ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97453 |
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code |
C97453 |
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DEFINITION |
A substance structurally unlike a nucleoside molecule that is capable of inhibiting the function of a reverse transcriptase. These compounds do not bind to the active site of the polymerase but in a less conserved pocket near the active site, causing a distortion in the shape of the active site and resulting in inhibition of enzymatic function, chain termination, and inhibition of viral replication. |
|
FULL_SYN |
Non-nucleoside Reverse Transcriptase Inhibitor NNRTI |
|
label |
Non-nucleoside Reverse Transcriptase Inhibitor |
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Preferred_Name |
Non-nucleoside Reverse Transcriptase Inhibitor |
|
prefixIRI |
Thesaurus:C97453 |
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Semantic_Type |
Chemical Viewed Functionally |
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UMLS_CUI |
C1373120 |
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subClassOf |