Preferred Name |
Zidovudine |
|
Synonyms |
3'-Azido-3'-deoxythymidine 1-(3-Azido-2,3-dideoxy-beta-D-ribofuranosyl)-5-methylpyrimidine-2,4-(1H,3H)-dione Azidothymidine AZT Aztec BW A509U BW-A 509U BW-A509U Compound S DRG-0004 Retrovir ZDV ZIDOVUDINE Zidovudine zidovudine |
|
Definitions |
A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. This agent also decreases levels of available pyrimidines. (NCI04) |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C947 |
|
Accepted_Therapeutic_Use_For |
AIDs-related complex; HIV infection; HIV transmission, prevention |
|
ALT_DEFINITION |
A drug that inhibits the human immunodeficiency virus (HIV) that causes AIDS. It is a type of systemic antiviral. |
|
CAS_Registry |
30516-87-1 |
|
CHEBI_ID |
CHEBI:10110 |
|
Chemical_Formula |
C10H13N5O4 |
|
code |
C947 |
|
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
|
Contributing_Source |
CTRP FDA HemOnc |
|
DEFINITION |
A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. This agent also decreases levels of available pyrimidines. (NCI04) |
|
Display_Name |
Zidovudine |
|
FDA_UNII_Code |
4B9XT59T7S |
|
FULL_SYN |
3'-Azido-3'-deoxythymidine 1-(3-Azido-2,3-dideoxy-beta-D-ribofuranosyl)-5-methylpyrimidine-2,4-(1H,3H)-dione Azidothymidine AZT Aztec BW A509U BW-A 509U BW-A509U Compound S DRG-0004 Retrovir ZDV ZIDOVUDINE Zidovudine zidovudine |
|
label |
Zidovudine |
|
Legacy Concept Name |
Zidovudine |
|
NCI_Drug_Dictionary_ID |
40121 |
|
NSC Number |
602670 |
|
PDQ_Closed_Trial_Search_ID |
40121 |
|
PDQ_Open_Trial_Search_ID |
40121 |
|
Preferred_Name |
Zidovudine |
|
prefixIRI |
Thesaurus:C947 |
|
Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide |
|
UMLS_CUI |
C0043474 |
|
subClassOf |