Preferred Name |
Warfarin |
|
Synonyms |
3-(Alpha-acetonylbenzyl)-4-hydroxycoumarin 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one 3-Alpha-phenyl-beta-acetylethyl-4-hydroxycoumarin Compound 42 WARF Compound 42 3-(.alpha.-Acetonylbenzyl)-4-hydroxycoumarin WARF compound 42 3-(.alpha.-Phenyl-.beta.-acetylethyl)-4-hydroxycoumarin 1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone Co-Rax Rodex WARFARIN Warfarin warfarin |
|
Definitions |
A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C945 |
|
Accepted_Therapeutic_Use_For |
Pulmonary embolism and thromboembolic disorders, treatment and prophylaxis; Venous thrombosis, prophylaxis and treatment |
|
ALT_DEFINITION |
A vitamin K antagonist anticoagulant A drug that prevents blood from clotting. It belongs to the family of drugs called anticoagulants (blood thinners). |
|
CAS_Registry |
81-81-2 |
|
CHEBI_ID |
CHEBI:10033 |
|
Chemical_Formula |
C19H16O4 |
|
code |
C945 |
|
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191406 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191670 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191200 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191387 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191405 |
|
Contributing_Source |
ACC/AHA CTRP FDA HemOnc |
|
DEFINITION |
A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity. |
|
Display_Name |
Warfarin |
|
FDA_UNII_Code |
5Q7ZVV76EI |
|
FULL_SYN |
3-(Alpha-acetonylbenzyl)-4-hydroxycoumarin 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one 3-Alpha-phenyl-beta-acetylethyl-4-hydroxycoumarin Compound 42 WARF Compound 42 3-(.alpha.-Acetonylbenzyl)-4-hydroxycoumarin WARF compound 42 3-(.alpha.-Phenyl-.beta.-acetylethyl)-4-hydroxycoumarin 1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone Co-Rax Rodex WARFARIN Warfarin warfarin |
|
Has_ACC-AHA_SARS2_Authorized_Value |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17998 |
|
Has_Salt_Form | ||
label |
Warfarin |
|
Legacy Concept Name |
Warfarin |
|
NCI_Drug_Dictionary_ID |
39740 |
|
NSC Number |
59813 |
|
PDQ_Closed_Trial_Search_ID |
39740 |
|
PDQ_Open_Trial_Search_ID |
39740 |
|
Preferred_Name |
Warfarin |
|
prefixIRI |
Thesaurus:C945 |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
UMLS_CUI |
C0043031 |
|
subClassOf |