National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Warfarin

Synonyms

3-(Alpha-acetonylbenzyl)-4-hydroxycoumarin

4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one

3-Alpha-phenyl-beta-acetylethyl-4-hydroxycoumarin

Compound 42

WARF Compound 42

3-(.alpha.-Acetonylbenzyl)-4-hydroxycoumarin

WARF compound 42

3-(.alpha.-Phenyl-.beta.-acetylethyl)-4-hydroxycoumarin

1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone

Co-Rax

Rodex

WARFARIN

Warfarin

warfarin

Definitions

A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C945

Accepted_Therapeutic_Use_For

Pulmonary embolism and thromboembolic disorders, treatment and prophylaxis; Venous thrombosis, prophylaxis and treatment

ALT_DEFINITION

A vitamin K antagonist anticoagulant

A drug that prevents blood from clotting. It belongs to the family of drugs called anticoagulants (blood thinners).

CAS_Registry

81-81-2

CHEBI_ID

CHEBI:10033

Chemical_Formula

C19H16O4

code

C945

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191406

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191670

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191200

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191387

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191405

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191671

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

ACC/AHA

CTRP

FDA

HemOnc

DEFINITION

A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity.

Display_Name

Warfarin

FDA_UNII_Code

5Q7ZVV76EI

FULL_SYN

3-(Alpha-acetonylbenzyl)-4-hydroxycoumarin

4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one

3-Alpha-phenyl-beta-acetylethyl-4-hydroxycoumarin

Compound 42

WARF Compound 42

3-(.alpha.-Acetonylbenzyl)-4-hydroxycoumarin

WARF compound 42

3-(.alpha.-Phenyl-.beta.-acetylethyl)-4-hydroxycoumarin

1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone

Co-Rax

Rodex

WARFARIN

Warfarin

warfarin

Has_ACC-AHA_SARS2_Authorized_Value

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17998

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49488

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49487

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66658

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1658

label

Warfarin

Legacy Concept Name

Warfarin

NCI_Drug_Dictionary_ID

39740

NSC Number

59813

PDQ_Closed_Trial_Search_ID

39740

PDQ_Open_Trial_Search_ID

39740

Preferred_Name

Warfarin

prefixIRI

Thesaurus:C945

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0043031

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45597

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173064

Delete Subject Author Type Created
No notes to display
Create mapping

Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_10033 OBA LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02640 MIO LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_e4a06e5e_bdd1_49fc_814a_47a41d12ec58 STO-DRAFT LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_e4a06e5e_bdd1_49fc_814a_47a41d12ec58 CVAO LOOM
http://stirdf.jst.go.jp/id/200907082204646470 IOBC LOOM
http://www.ustb.edu.cn/thesauri/tocr/v1/data#C571352688529240169 ACVD_ONTOLOGY LOOM
http://purl.bioontology.org/ontology/NDDF/002084 NDDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148057 NDFRT LOOM
http://purl.obolibrary.org/obo/OMIT_0015688 OMIT LOOM
http://bmi.utah.edu/ontologies/peontology/C0043031 PE LOOM
http://purl.jp/bio/4/id/200906041207325087 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.150.446.520.914 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907035077542769 IOBC LOOM
http://bmi.utah.edu/ontologies/hfontology/C0043031 HFO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.830.219.446.520.914 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D014859 MESH LOOM
http://www.co-ode.org/ontologies/galen#Warfarin GALEN LOOM
http://purl.obolibrary.org/obo/MESH_D014859 BERO LOOM
http://purl.bioontology.org/ontology/CSP/0397-0420 CRISP LOOM
http://stirdf.jst.go.jp/id/200907061659150750 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0043031 OCHV LOOM
https://go.drugbank.com/drugs/DB00682 MDM LOOM
http://purl.obolibrary.org/obo/NCIT_C945 BERO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#13106 OCHV LOOM
http://purl.bioontology.org/ontology/RCD/x01O4 RCD LOOM
http://purl.bioontology.org/ontology/RXNORM/11289 RXNORM LOOM
http://www.drugbank.ca/drugs/DB00682 FTC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017666 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003212 LOINC LOOM
http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Warfarin PCAO LOOM
http://purl.obolibrary.org/obo/CHEBI_10033 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_10033 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_10033 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_10033 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_10033 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_10033 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_10033 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_10033 OBA LOOM
http://purl.obolibrary.org/obo/CHEBI_10033 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_10033 NIFSTD LOOM
http://purl.bioontology.org/ontology/SNMI/C-A6530 SNMI LOOM
http://purl.jp/bio/4/id/200906087586835534 IOBC LOOM
http://purl.jp/bio/4/id/200906089236296382 IOBC LOOM
http://purl.bioontology.org/ontology/ATC/B01AA03 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D014859 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/LA28654-4 LOINC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372756006 SNOMEDCT LOOM
http://www.gamuts.net/entity#warfarin GAMUTS LOOM
http://purl.bioontology.org/ontology/LNC/LP16309-4 LOINC LOOM
http://purl.bioontology.org/ontology/VANDF/4019972 VANDF LOOM
http://www.genomic-cds.org/ont/genomic-cds.owl#Warfarin GENE-CDS LOOM