loading...| Preferred Name |
Vindesine |
|
| Synonyms |
Deacetylvinblastine Carboxamide Desacetylvinblastine Amide Compound 112531 3-(Aminocarbonyl)-O4-deacetyl-3-de-(methoxycarbonyl)vincaleukoblastine Lilly CT-3231 Deacetyl Vinblastine Carboxamide DAVA DVA VDS VINDESINE Vindesine vindesine |
|
| Definitions |
A synthetic derivative of vinblastine, a naturally occurring vinca alkaloid. Vindesine binds to and stabilizes tubulin, thereby interrupting tubulin polymerization and preventing the formation of the mitotic spindle and cell division; treated cells are unable to undergo mitosis and are arrested in metaphase. This agent also disrupts macromolecular synthesis. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C934 |
|
| ALT_DEFINITION |
An anticancer drug that belongs to the family of plant drugs called vinca alkaloids. |
|
| CAS_Registry |
53643-48-4 |
|
| CHEBI_ID |
CHEBI:36373 |
|
| Chemical_Formula |
C43H55N5O7 |
|
| code |
C934 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
FDA GDC HemOnc |
|
| DEFINITION |
A synthetic derivative of vinblastine, a naturally occurring vinca alkaloid. Vindesine binds to and stabilizes tubulin, thereby interrupting tubulin polymerization and preventing the formation of the mitotic spindle and cell division; treated cells are unable to undergo mitosis and are arrested in metaphase. This agent also disrupts macromolecular synthesis. (NCI04) |
|
| FDA_UNII_Code |
RSA8KO39WH |
|
| FULL_SYN |
Deacetylvinblastine Carboxamide Desacetylvinblastine Amide Compound 112531 3-(Aminocarbonyl)-O4-deacetyl-3-de-(methoxycarbonyl)vincaleukoblastine Lilly CT-3231 Deacetyl Vinblastine Carboxamide DAVA DVA VDS VINDESINE Vindesine vindesine |
|
| Has_Salt_Form | ||
| Is_Value_For_GDC_Property | ||
| label |
Vindesine |
|
| Legacy Concept Name |
Vindesine |
|
| Maps_To |
Vindesine |
|
| NCI_Drug_Dictionary_ID |
39732 |
|
| PDQ_Closed_Trial_Search_ID |
39732 |
|
| PDQ_Open_Trial_Search_ID |
39732 |
|
| Preferred_Name |
Vindesine |
|
| prefixIRI |
Thesaurus:C934 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0042682 |
|
| subClassOf |