National Cancer Institute Thesaurus

Last uploaded: August 27, 2019
Preferred Name

Verapamil

Synonyms

VERAPAMIL

Verapamil

alpha-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile

Definitions

A phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C928

CAS_Registry

52-53-9

CHEBI_ID

CHEBI:9948

Chemical_Formula

C27H38N2O4

code

C928

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)

Display_Name

Verapamil

FDA_UNII_Code

CJ0O37KU29

FULL_SYN

VERAPAMIL

Verapamil

alpha-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2827

label

Verapamil

Legacy_Concept_Name

Verapamil

PDQ_Closed_Trial_Search_ID

39730

PDQ_Open_Trial_Search_ID

39730

Preferred_Name

Verapamil

prefixIRI

ncit:C928

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0042523

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C333

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/PDQ/CDR0000039730 PDQ LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.092.471.683.953 RH-MESH LOOM
http://d-nb.info/gnd/4062550-3 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/NDDF/004515 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D014700 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372754009 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/MTHU007771 LOINC LOOM
http://purl.jp/bio/4/id/200906047107040601 IOBC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148054 NDFRT LOOM
http://bmi.utah.edu/ontologies/hfontology/C0042523 HFO LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148054 OCVDAE LOOM
http://www.drugbank.ca/drugs/DB00661 FTC LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Verapamil APAONTO LOOM
http://purl.bioontology.org/ontology/SNMI/C-80490 SNMI LOOM
http://stirdf.jst.go.jp/id/200907065943493604 IOBC LOOM
http://purl.obolibrary.org/obo/CHEBI_9948 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_9948 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_9948 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9948 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_9948 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_9948 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_9948 DRON LOOM
http://purl.bioontology.org/ontology/CSP/2268-7394 CRISP LOOM
http://doe-generated-ontology.com/OntoAD#C0042523 ONTOAD LOOM
http://purl.bioontology.org/ontology/MESH/D014700 MESH LOOM
http://purl.bioontology.org/ontology/RCD/x01QU RCD LOOM
http://stirdf.jst.go.jp/id/200907001651458621 IOBC LOOM
http://purl.jp/bio/4/id/200906076642470240 IOBC LOOM
http://purl.bioontology.org/ontology/RXNORM/11170 RXNORM LOOM
http://stirdf.jst.go.jp/id/200907009098573680 IOBC LOOM
http://purl.jp/bio/4/id/200906017005265599 IOBC LOOM
http://purl.bioontology.org/ontology/UATC/C08DA01 ATC LOOM
http://stirdf.jst.go.jp/id/200907073876348656 IOBC LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#verapamil SDO LOOM
http://purl.bioontology.org/ontology/VANDF/4019969 VANDF LOOM
http://purl.obolibrary.org/obo/XCO_0000616 XCO LOOM
http://www.gamuts.net/entity#verapamil GAMUTS LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006181 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006181 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006181 DMTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006187 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006187 DMTO LOOM
http://purl.bioontology.org/ontology/LNC/LP16307-8 LOINC LOOM
http://www.co-ode.org/ontologies/galen#Verapamil GALEN LOOM
http://purl.jp/bio/4/id/200906075738916960 IOBC LOOM
http://id.loc.gov/authorities/subjects/sh93000011 FAST-TOPICAL LOOM