National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Amantadine Sulfate

Synonyms

Amantadine Sulfate

AMANTADINE SULFATE

Definitions

The sulfate salt of amantadine, a synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells; furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90781

CAS_Registry

31377-23-8

Chemical_Formula

2C10H17N.H2O4S

code

C90781

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

The sulfate salt of amantadine, a synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells; furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia.

FDA_UNII_Code

9921T5P019

FULL_SYN

Amantadine Sulfate

AMANTADINE SULFATE

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61632

label

Amantadine Sulfate

Preferred_Name

Amantadine Sulfate

prefixIRI

Thesaurus:C90781

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0002404

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C281

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C93038

Delete Subject Author Type Created
No notes to display