National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Tretinoin

Synonyms

Retin-A MICRO

Retin-A-Micro

all-trans-Vitamin A acid

trans-Retinoic Acid

All-trans retinoic acid

Vitamin A acid

retinoic acid

Stieva-A Forte

All-trans Retinoic Acid

Trans Vitamin A Acid

Trans Retinoic Acid

Vitamin A acid, all-trans-

Vitamin A Acid

trans-Retinoic acid

Retinoic Acid

Tretinoinum

all-trans-Retinoic acid

all trans-Retinoic acid

2,4,6,8-Nonatetraenoic acid, 3, 7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all-E)-

All-trans Vitamin A Acid

all-trans retinoic acid

(All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid

vitamin A acid

beta-Retinoic Acid

ATRA

Aberel

Airol

Aknoten

Avita

Cordes Vas

Dermairol

Epi-Aberel

Eudyna

Renova

Retin-A

Retisol-A

Ro 5488

Stieva-A

TRETINOIN

Tretinoin

Vesanoid

Vitinoin

tretinoin

Definitions

A naturally-occurring acid of retinol. Tretinoin binds to and activates retinoic acid receptors (RARs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, and inhibition of tumorigenesis. This agent also inhibits telomerase, resulting in telomere shortening and eventual apoptosis of some tumor cell types. The oral form of tretinoin has teratogenic and embryotoxic properties.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C900

Accepted_Therapeutic_Use_For

(Topical) acne vulgaris; other dermatologic conditions; some skin cancers

(Oral) Acute promyelocytic leukemia (APL), characterized by the t(15;17) translocation or the PML/RARa gene refractory to or have relapsed from anthracycline chemotherapy, or for where anthracycline-based chemotherapy is contraindicated

ALT_DEFINITION

A nutrient that that body needs in small amounts to function and stay healthy. All-trans retinoic acid is made in the body from vitamin A and helps cells to grow and develop, especially in the embryo. A form of all-trans retinoic acid made in the laboratory is put on the skin to treat conditions such as acne and is taken by mouth to treat acute promyelocytic leukemia (a fast-growing cancer in which there are too many immature blood-forming cells in the blood and bone marrow). All-trans retinoic acid is being studied in the prevention and treatment of other types of cancer.

CAS_Registry

302-79-4

CHEBI_ID

CHEBI:15367

Chemical_Formula

C20H28O2

code

C900

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173234

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C174019

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

CTRP

FDA

GDC

HemOnc

PCDC

DEFINITION

A naturally-occurring acid of retinol. Tretinoin binds to and activates retinoic acid receptors (RARs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, and inhibition of tumorigenesis. This agent also inhibits telomerase, resulting in telomere shortening and eventual apoptosis of some tumor cell types. The oral form of tretinoin has teratogenic and embryotoxic properties.

Display_Name

Tretinoin

FDA_UNII_Code

5688UTC01R

FULL_SYN

Retin-A MICRO

Retin-A-Micro

all-trans-Vitamin A acid

trans-Retinoic Acid

All-trans retinoic acid

Vitamin A acid

retinoic acid

Stieva-A Forte

All-trans Retinoic Acid

Trans Vitamin A Acid

Trans Retinoic Acid

Vitamin A acid, all-trans-

Vitamin A Acid

trans-Retinoic acid

Retinoic Acid

Tretinoinum

all-trans-Retinoic acid

all trans-Retinoic acid

2,4,6,8-Nonatetraenoic acid, 3, 7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all-E)-

All-trans Vitamin A Acid

all-trans retinoic acid

(All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid

vitamin A acid

beta-Retinoic Acid

ATRA

Aberel

Airol

Aknoten

Avita

Cordes Vas

Dermairol

Epi-Aberel

Eudyna

Renova

Retin-A

Retisol-A

Ro 5488

Stieva-A

TRETINOIN

Tretinoin

Vesanoid

Vitinoin

tretinoin

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17532

Is_PCDC_AML_Authorized_Value_For_Variable

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C274

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Tretinoin

Legacy Concept Name

Vitamin_A_Acid

Maps_To

Tretinoin

NCI_Drug_Dictionary_ID

41258

NSC Number

122758

PDQ_Closed_Trial_Search_ID

41258

PDQ_Open_Trial_Search_ID

41258

Preferred_Name

Tretinoin

prefixIRI

Thesaurus:C900

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0040845

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C804

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/ATC/L01XF01 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D23.767.261.700.780 RH-MESH LOOM
http://purl.obolibrary.org/obo/NCIT_C900 BERO LOOM
http://purl.bioontology.org/ontology/RCD/x03pf RCD LOOM
http://purl.bioontology.org/ontology/MESH/D014212 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.849.131.495.818.800 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146871 NDFRT LOOM
http://www.co-ode.org/ontologies/galen#Tretinoin GALEN LOOM
https://go.drugbank.com/drugs/DB00755 MDM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.392.368.367.379.249.700.860.500 RH-MESH LOOM
http://doe-generated-ontology.com/OntoAD#C0040845 ONTOAD LOOM
http://www.drugbank.ca/drugs/DB00755 FTC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#12512 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.326.271.665.202.495.818.500 RH-MESH LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000041258 PDQ LOOM
http://purl.obolibrary.org/obo/CHEBI_15367 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_15367 DRON LOOM
http://purl.obolibrary.org/obo/MESH_D014212 BERO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387305002 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/OMIT_0015051 OMIT LOOM
http://purl.bioontology.org/ontology/VANDF/4018550 VANDF LOOM
http://purl.bioontology.org/ontology/SNMI/C-92010 SNMI LOOM
http://purl.bioontology.org/ontology/ATC/D10AD01 ATC LOOM
http://purl.obolibrary.org/obo/MCBCC_0000270#Tretinoin MCBCC LOOM
http://purl.jp/bio/4/id/200906081568041395 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0040845 OCHV LOOM
http://purl.bioontology.org/ontology/RXNORM/10753 RXNORM LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016677 PMAPP-PMO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D014212 RH-MESH LOOM