National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Tinidazole

Synonyms

Fasigyn

Simplotan

TDZ

TINIDAZOLE

Tindamax

Tinidazole

tinidazole

Definitions

A 5-nitroimidazole derivative with antiprotozoal property. Although the mechanism of action has not been fully elucidated, it has been suggested that tinidazole is metabolized and yields nitrite anions and metronidazole. Metronidazole's nitro group in turn is reduced via the parasite ferredoxin, thereby generating a series of free nitro radicals including nitro anions. Toxicity is achieved via depletion of sulfhydryl groups and DNA strand breaks with multiple hits having an additive effect and ultimately leading to cell death.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C890

ALT_DEFINITION

A drug used to treat protozoal infections, such as amebiasis, giardiasis, and trichomoniasis. It belongs to a family of drugs called antiprotozoal agents. Tinidazole is also being evaluated in the treatment of Helicobacter pylori infections in people with low-grade gastric lymphoma.

CAS_Registry

19387-91-8

25459-12-5

CHEBI_ID

CHEBI:63627

Chemical_Formula

C8H13N3O4S

code

C890

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A 5-nitroimidazole derivative with antiprotozoal property. Although the mechanism of action has not been fully elucidated, it has been suggested that tinidazole is metabolized and yields nitrite anions and metronidazole. Metronidazole's nitro group in turn is reduced via the parasite ferredoxin, thereby generating a series of free nitro radicals including nitro anions. Toxicity is achieved via depletion of sulfhydryl groups and DNA strand breaks with multiple hits having an additive effect and ultimately leading to cell death.

FDA_UNII_Code

033KF7V46H

FULL_SYN

Fasigyn

Simplotan

TDZ

TINIDAZOLE

Tindamax

Tinidazole

tinidazole

label

Tinidazole

Legacy Concept Name

Tinidazole

NCI_Drug_Dictionary_ID

43288

PDQ_Closed_Trial_Search_ID

43288

PDQ_Open_Trial_Search_ID

43288

Preferred_Name

Tinidazole

prefixIRI

Thesaurus:C890

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0040263

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C277

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http://purl.bioontology.org/ontology/NDDF/004057 NDDF LOOM
https://go.drugbank.com/drugs/DB00911 MDM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/395907001 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D014011 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/10612 RXNORM LOOM
http://purl.obolibrary.org/obo/MESH_D014011 BERO LOOM
http://purl.bioontology.org/ontology/ATC/G01AF21 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.640.672.900 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.129.308.658.900 RH-MESH LOOM
http://purl.obolibrary.org/obo/OMIT_0014854 OMIT LOOM
http://purl.bioontology.org/ontology/MESH/D014011 MESH LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148851 ODAE LOOM
http://purl.obolibrary.org/obo/CHEBI_63627 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_63627 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_63627 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_63627 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_63627 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_63627 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_63627 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_63627 ODNAE LOOM
http://purl.bioontology.org/ontology/ATC/P01AB02 ATC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017229 PMAPP-PMO LOOM
http://purl.jp/bio/4/id/200906052739683250 IOBC LOOM
http://purl.obolibrary.org/obo/NCIT_C890 BERO LOOM
http://purl.bioontology.org/ontology/VANDF/4021467 VANDF LOOM
http://purl.bioontology.org/ontology/LNC/MTHU032217 LOINC LOOM
http://purl.obolibrary.org/obo/ARO_3004026 ARO LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000043288 PDQ LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148851 NDFRT LOOM
http://stirdf.jst.go.jp/id/200907079756355339 IOBC LOOM
http://www.co-ode.org/ontologies/galen#Tinidazole GALEN LOOM
http://purl.bioontology.org/ontology/ATC/J01XD02 ATC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#12310 OCHV LOOM
http://purl.bioontology.org/ontology/RCD/ef2.. RCD LOOM
http://purl.bioontology.org/ontology/LNC/LP90845-6 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0040263 OCHV LOOM