National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Thiamine

Synonyms

2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-1-thia-3-azoniacyclopenta-2,4-dien-5-yl]ethanol

Aneurin

B1 Vitamin

THIAMINE

Thiamin

Thiamine

Vit B1

Vitamin B1

Vitamin-B1

thiamine

vitamin B1

Definitions

A heat-labile and water-soluble essential vitamin, belonging to the vitamin B family, with antioxidant, erythropoietic, mood modulating, and glucose-regulating activities. Thiamine reacts with adenosine triphosphate (ATP) to form an active coenzyme, thiamine pyrophosphate. Thiamine pyrophosphate is necessary for the actions of pyruvate dehydrogenase and alpha-ketoglutarate in carbohydrate metabolism and for the actions of transketolase, an enzyme that plays an important role in the pentose phosphate pathway. Thiamine plays a key role in intracellular glucose metabolism and may inhibit the action of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine may also protect against lead toxicity by inhibiting lead-induced lipid peroxidation.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C874

ALT_DEFINITION

A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Vitamin B1 helps some enzymes work properly, helps break down sugars in the diet, and keeps nerves and the heart healthy. It is found in pork, organ meats, peas, beans, nuts, and whole grains. Vitamin B1 is water-soluble (can dissolve in water) and must be taken in daily. Not enough vitamin B1 can cause a disease called beriberi (a condition marked by heart, nerve, and digestive disorders). Too much vitamin B1 may help cancer cells grow faster.

Water-soluble vitamin that is a coenzyme in the metabolism of carbohydrates and branched-chain amino acids. (DRI)

CAS_Registry

59-43-8

CHEBI_ID

CHEBI:33283

Chemical_Formula

C12H17N4OS.Cl

code

C874

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CRCH

CTRP

FDA

DEFINITION

A heat-labile and water-soluble essential vitamin, belonging to the vitamin B family, with antioxidant, erythropoietic, mood modulating, and glucose-regulating activities. Thiamine reacts with adenosine triphosphate (ATP) to form an active coenzyme, thiamine pyrophosphate. Thiamine pyrophosphate is necessary for the actions of pyruvate dehydrogenase and alpha-ketoglutarate in carbohydrate metabolism and for the actions of transketolase, an enzyme that plays an important role in the pentose phosphate pathway. Thiamine plays a key role in intracellular glucose metabolism and may inhibit the action of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine may also protect against lead toxicity by inhibiting lead-induced lipid peroxidation.

Display_Name

Thiamine

FDA_UNII_Code

X66NSO3N35

FULL_SYN

2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-1-thia-3-azoniacyclopenta-2,4-dien-5-yl]ethanol

Aneurin

B1 Vitamin

THIAMINE

Thiamin

Thiamine

Vit B1

Vitamin B1

Vitamin-B1

thiamine

vitamin B1

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48025

INFOODS

THIA

label

Thiamine

Legacy Concept Name

Thiamine

Micronutrient

Y

NCI_Drug_Dictionary_ID

37856

Nutrient

Y

PDQ_Closed_Trial_Search_ID

37856

PDQ_Open_Trial_Search_ID

37856

Preferred_Name

Thiamine

prefixIRI

Thesaurus:C874

Semantic_Type

Organic Chemical

Vitamin

UMLS_CUI

C0039840

Unit

mg

US_Recommended_Intake

Y

USDA_ID

404

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45812

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/OMIT_0014681 OMIT LOOM
http://purl.bioontology.org/ontology/SNMI/F-BB310 SNMI LOOM
http://purl.jp/bio/10/gmo/GMO_001230 GMO LOOM
http://purl.bioontology.org/ontology/VANDF/4017474 VANDF LOOM
http://purl.bioontology.org/ontology/RXNORM/10454 RXNORM LOOM
http://www.co-ode.org/ontologies/galen#Thiamine GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.129.708.900 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000145862 NDFRT LOOM
http://www.drugbank.ca/drugs/DB00152 FTC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0039840 OCHV LOOM
http://purl.obolibrary.org/obo/UPa_UPC00378 UPA LOOM
https://go.drugbank.com/drugs/DB00152 MDM LOOM
http://purl.bioontology.org/ontology/MESH/D013831 MESH LOOM
http://purl.bioontology.org/ontology/LNC/LP15886-2 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#12172 OCHV LOOM
http://localhost/plosthes.2017-1#3994 PLOSTHES LOOM
http://purl.obolibrary.org/obo/NCIT_C874 BERO LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017476 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/VANDF/4021900 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.742.795 RH-MESH LOOM
http://purl.obolibrary.org/obo/MESH_D013831 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.675.900 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D013831 RH-MESH LOOM
http://purl.bioontology.org/ontology/CSP/3147-2928 CRISP LOOM
http://bmi.utah.edu/ontologies/hfontology/C0039840 HFO LOOM
http://purl.obolibrary.org/obo/dinto_DB00152 DINTO LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000037856 PDQ LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/259659006 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/CHEBI_26948 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_26948 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_26948 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_26948 ONSTR LOOM
http://purl.obolibrary.org/obo/CHEBI_26948 HINO LOOM
http://purl.obolibrary.org/obo/CHEBI_26948 MCO LOOM
http://purl.bioontology.org/ontology/MEDLINEPLUS/C0039840 MEDLINEPLUS LOOM
http://purl.bioontology.org/ontology/LNC/MTHU008943 LOINC LOOM
http://purl.bioontology.org/ontology/MEDDRA/10058787 MEDDRA LOOM