National Cancer Institute Thesaurus

Last uploaded: February 4, 2019
Preferred Name

Sodium Selenite

Synonyms

Selenious Acid Disodium Salt

Selenious Acid, Sodium Salt (1:2)

SODIUM SELENITE

Sodium Selenite

Disodium Selenium Trioxide

Definitions

An inorganic form of the trace element selenium with potential antineoplastic activity. Selenium, administered in the form of sodium selenite, is reduced to hydrogen selenide (H2Se) in the presence of glutathione (GSH) and subsequently generates superoxide radicals upon reaction with oxygen. This may inhibit the expression and activity of the transcription factor Sp1; in turn Sp1 down-regulates androgen receptor (AR) expression and blocks AR signaling. Eventually, selenium may induce apoptosis in prostate cancer cells and inhibit tumor cell proliferation.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C87346

CAS_Registry

10102-18-8

CHEBI_ID

CHEBI:48843

Chemical_Formula

2Na.O3Se

code

C87346

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

An inorganic form of the trace element selenium with potential antineoplastic activity. Selenium, administered in the form of sodium selenite, is reduced to hydrogen selenide (H2Se) in the presence of glutathione (GSH) and subsequently generates superoxide radicals upon reaction with oxygen. This may inhibit the expression and activity of the transcription factor Sp1; in turn Sp1 down-regulates androgen receptor (AR) expression and blocks AR signaling. Eventually, selenium may induce apoptosis in prostate cancer cells and inhibit tumor cell proliferation.

Display_Name

Sodium Selenite

FDA_UNII_Code

HIW548RQ3W

FULL_SYN

Selenious Acid Disodium Salt

Selenious Acid, Sodium Salt (1:2)

SODIUM SELENITE

Sodium Selenite

Disodium Selenium Trioxide

label

Sodium Selenite

PDQ_Closed_Trial_Search_ID

681583

PDQ_Open_Trial_Search_ID

681583

Preferred_Name

Sodium Selenite

prefixIRI

ncit:C87346

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0142923

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1505

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