National Cancer Institute Thesaurus

Last uploaded: October 28, 2019
Preferred Name

Sodium Selenite

Synonyms

Selenious Acid Disodium Salt

Selenious Acid, Sodium Salt (1:2)

SODIUM SELENITE

Sodium Selenite

Disodium Selenium Trioxide

Definitions

An inorganic form of the trace element selenium with potential antineoplastic activity. Selenium, administered in the form of sodium selenite, is reduced to hydrogen selenide (H2Se) in the presence of glutathione (GSH) and subsequently generates superoxide radicals upon reaction with oxygen. This may inhibit the expression and activity of the transcription factor Sp1; in turn Sp1 down-regulates androgen receptor (AR) expression and blocks AR signaling. Eventually, selenium may induce apoptosis in prostate cancer cells and inhibit tumor cell proliferation.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C87346

CAS_Registry

10102-18-8

CHEBI_ID

CHEBI:48843

Chemical_Formula

2Na.O3Se

code

C87346

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

An inorganic form of the trace element selenium with potential antineoplastic activity. Selenium, administered in the form of sodium selenite, is reduced to hydrogen selenide (H2Se) in the presence of glutathione (GSH) and subsequently generates superoxide radicals upon reaction with oxygen. This may inhibit the expression and activity of the transcription factor Sp1; in turn Sp1 down-regulates androgen receptor (AR) expression and blocks AR signaling. Eventually, selenium may induce apoptosis in prostate cancer cells and inhibit tumor cell proliferation.

Display_Name

Sodium Selenite

FDA_UNII_Code

HIW548RQ3W

FULL_SYN

Selenious Acid Disodium Salt

Selenious Acid, Sodium Salt (1:2)

SODIUM SELENITE

Sodium Selenite

Disodium Selenium Trioxide

label

Sodium Selenite

PDQ_Closed_Trial_Search_ID

681583

PDQ_Open_Trial_Search_ID

681583

Preferred_Name

Sodium Selenite

prefixIRI

ncit:C87346

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0142923

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1505

Delete Subject Author Type Created
No notes to display
Create New Mapping

Delete Mapping To Ontology Source
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D01.857.850 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D018038 MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0142923 OCHV LOOM
http://purl.jp/bio/10/gmo/GMO_001093 GMO LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000681583 PDQ LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/96277001 SNOMEDCT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#16510 OCHV LOOM
http://purl.bioontology.org/ontology/SNMI/C-71091 SNMI LOOM
http://purl.bioontology.org/ontology/NDDF/005523 NDDF LOOM
http://purl.obolibrary.org/obo/CHEBI_48843 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_48843 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_48843 EFO LOOM
http://purl.bioontology.org/ontology/VANDF/4020869 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148373 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D018038 RH-MESH LOOM
http://purl.bioontology.org/ontology/UATC/A12CE02 ATC LOOM
http://purl.bioontology.org/ontology/RXNORM/56519 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D01.810.900.500 RH-MESH LOOM