loading...| Preferred Name |
Sodium Selenite |
|
| Synonyms |
Disodium Selenium Trioxide SODIUM SELENITE Sodium Selenite Selenious Acid, Sodium Salt (1:2) Selenious Acid Disodium Salt |
|
| Definitions |
An inorganic form of the trace element selenium with potential antineoplastic activity. Selenium, administered in the form of sodium selenite, is reduced to hydrogen selenide (H2Se) in the presence of glutathione (GSH) and subsequently generates superoxide radicals upon reaction with oxygen. This may inhibit the expression and activity of the transcription factor Sp1; in turn Sp1 down-regulates androgen receptor (AR) expression and blocks AR signaling. Eventually, selenium may induce apoptosis in prostate cancer cells and inhibit tumor cell proliferation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C87346 |
|
| CAS_Registry |
10102-18-8 |
|
| CHEBI_ID |
CHEBI:48843 |
|
| Chemical_Formula |
2Na.O3Se |
|
| code |
C87346 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
An inorganic form of the trace element selenium with potential antineoplastic activity. Selenium, administered in the form of sodium selenite, is reduced to hydrogen selenide (H2Se) in the presence of glutathione (GSH) and subsequently generates superoxide radicals upon reaction with oxygen. This may inhibit the expression and activity of the transcription factor Sp1; in turn Sp1 down-regulates androgen receptor (AR) expression and blocks AR signaling. Eventually, selenium may induce apoptosis in prostate cancer cells and inhibit tumor cell proliferation. |
|
| Display_Name |
Sodium Selenite |
|
| FDA_UNII_Code |
HIW548RQ3W |
|
| FULL_SYN |
Disodium Selenium Trioxide SODIUM SELENITE Sodium Selenite Selenious Acid, Sodium Salt (1:2) Selenious Acid Disodium Salt |
|
| Is_Value_For_GDC_Property | ||
| label |
Sodium Selenite |
|
| Maps_To |
Sodium Selenite |
|
| NCI_Drug_Dictionary_ID |
681583 |
|
| PDQ_Closed_Trial_Search_ID |
681583 |
|
| PDQ_Open_Trial_Search_ID |
681583 |
|
| Preferred_Name |
Sodium Selenite |
|
| prefixIRI |
Thesaurus:C87346 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0142923 |
|
| subClassOf |