loading...| Preferred Name |
Thiabendazole |
|
| Synonyms |
THIABENDAZOLE Thiabendazole MK 360 MK-360 Mintezol TBZ Thibenzole |
|
| Definitions |
A benzimidazole derivative with anthelminthic property. Although the mechanism of action has not been fully elucidated, thiabendazole inhibits the helminth-specific mitochondrial enzyme fumarate reductase, thereby inhibiting the citric acid cycle, mitochondrial respiration and subsequent production of ATP, ultimately leading to helminth's death. In addition, it has been suggested that thiabendazole may lead to inhibition of microtubule polymerization by binding to beta-tubulin and has an overt ovicidal effect with regard to some trichostrongylids. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C873 |
|
| CAS_Registry |
148-79-8 |
|
| CHEBI_ID |
CHEBI:45979 |
|
| Chemical_Formula |
C10H7N3S |
|
| code |
C873 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A benzimidazole derivative with anthelminthic property. Although the mechanism of action has not been fully elucidated, thiabendazole inhibits the helminth-specific mitochondrial enzyme fumarate reductase, thereby inhibiting the citric acid cycle, mitochondrial respiration and subsequent production of ATP, ultimately leading to helminth's death. In addition, it has been suggested that thiabendazole may lead to inhibition of microtubule polymerization by binding to beta-tubulin and has an overt ovicidal effect with regard to some trichostrongylids. |
|
| FDA_UNII_Code |
N1Q45E87DT |
|
| FULL_SYN |
THIABENDAZOLE Thiabendazole MK 360 MK-360 Mintezol TBZ Thibenzole |
|
| label |
Thiabendazole |
|
| Legacy Concept Name |
Thiabendazole |
|
| NCI_Drug_Dictionary_ID |
39713 |
|
| NSC Number |
90507 |
|
| PDQ_Closed_Trial_Search_ID |
39713 |
|
| PDQ_Open_Trial_Search_ID |
39713 |
|
| Preferred_Name |
Thiabendazole |
|
| prefixIRI |
Thesaurus:C873 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0039832 |
|
| subClassOf |