loading...| Preferred Name |
Tinzaparin |
|
| Synonyms |
B01AB10 TINZAPARIN Tinzaparin tinzaparin |
|
| Definitions |
A low molecular weight heparin (LMWH), obtained by controlled enzymatic depolymerization of heparin from porcine intestinal mucosa, with antithrombotic properties. Tinzaparin is a potent inhibitor of several activated coagulation factors, especially Factors Xa and IIa (thrombin); its primary activity is mediated through the plasma protease inhibitor antithrombin. In addition, this agent may inhibit angiogenesis through: 1) competitive binding of the heparin-binding sites on endothelial cells for the proangiogenic cytokines vascular endothelial growth factor (VEGF) and beta-fibroblast growth factor (beta-FGF) and 2) increasing the release of tissue factor pathway inhibitor (TFPI), a negative regulator of angiogenesis. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C87297 |
|
| ALT_DEFINITION |
A drug that is used with another drug, warfarin, to treat blood clots that form deep in the veins and to prevent new blood clots from forming. It is a type of anticoagulant. |
|
| CAS_Registry |
9005-49-6 |
|
| CHEBI_ID |
CHEBI:28304 |
|
| Chemical_Formula |
(C14H18NO11)n.2(C12H16NO13S)n.3HO3S |
|
| code |
C87297 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 |
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| Contributing_Source |
FDA HemOnc |
|
| DEFINITION |
A low molecular weight heparin (LMWH), obtained by controlled enzymatic depolymerization of heparin from porcine intestinal mucosa, with antithrombotic properties. Tinzaparin is a potent inhibitor of several activated coagulation factors, especially Factors Xa and IIa (thrombin); its primary activity is mediated through the plasma protease inhibitor antithrombin. In addition, this agent may inhibit angiogenesis through: 1) competitive binding of the heparin-binding sites on endothelial cells for the proangiogenic cytokines vascular endothelial growth factor (VEGF) and beta-fibroblast growth factor (beta-FGF) and 2) increasing the release of tissue factor pathway inhibitor (TFPI), a negative regulator of angiogenesis. |
|
| FDA_UNII_Code |
7UQ7X4Y489 |
|
| FULL_SYN |
B01AB10 TINZAPARIN Tinzaparin tinzaparin |
|
| Has_Salt_Form | ||
| label |
Tinzaparin |
|
| Preferred_Name |
Tinzaparin |
|
| prefixIRI |
Thesaurus:C87297 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0216278 |
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| subClassOf |