Preferred Name |
Thalidomide |
|
Synonyms |
Alpha-Phthalimidoglutarimide thalidomide Thalidomide (-)-Thalidomide Sedoval K17 Sedoval K-17 .alpha.-Phthalimidoglutarimide THALIDOMIDE 2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione N-Phthalylglutamic acid imide N-(2,6-Dioxo-3-piperidyl)phthalimide Phthalimide, N-(2, 6-dioxo-3-piperidyl)-, (+)- N-Phthalylglutamic Acid Imide (+)-Thalidomide 3-Phthalimidoglutarimide N-Phthaloylglutamimide 2, 6-Dioxo-3-phthalimidopiperidine 2,6-Dioxo-3-phthalimidopiperidine Phthalimide, N-(2, 6-dioxo-3-piperidyl)-, (-)- Contergan Distaval Kevadon Neurosedyn Pantosediv Sedalis Softenon Synovir Talimol Thalomid |
|
Definitions |
A synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties. Thalidomide acts primarily by inhibiting both the production of tumor necrosis factor alpha (TNF-alpha) in stimulated peripheral monocytes and the activities of interleukins and interferons. This agent also inhibits polymorphonuclear chemotaxis and monocyte phagocytosis. In addition, thalidomide inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), thereby inhibiting angiogenesis. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C870 |
|
Accepted_Therapeutic_Use_For |
Aphthous stomatitis; Crohns disease; cutaneous manifestations of erythema nodosum leprosum; GVHD; HIV-associated wasting syndrome; Karposi sarcoma; lepromatous leprosy; multiple myeloma; mycobacterium tuberculosis and nontuberculosis; primary brain tumors |
|
ALT_DEFINITION |
A drug that is used to treat multiple myeloma in patients who have just been diagnosed, and a painful skin disease related to leprosy. It is also being studied in the treatment of other types of cancer. Thalomid belongs to the family of drugs called angiogenesis inhibitors. |
|
CAS_Registry |
50-35-1 |
|
CHEBI_ID |
CHEBI:9513 |
|
Chemical_Formula |
C13H10N2O4 |
|
code |
C870 |
|
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
Contributing_Source |
CTRP FDA GDC HemOnc |
|
DEFINITION |
A synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties. Thalidomide acts primarily by inhibiting both the production of tumor necrosis factor alpha (TNF-alpha) in stimulated peripheral monocytes and the activities of interleukins and interferons. This agent also inhibits polymorphonuclear chemotaxis and monocyte phagocytosis. In addition, thalidomide inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), thereby inhibiting angiogenesis. |
|
Display_Name |
Thalidomide |
|
FDA_UNII_Code |
4Z8R6ORS6L |
|
FULL_SYN |
Alpha-Phthalimidoglutarimide thalidomide Thalidomide (-)-Thalidomide Sedoval K17 Sedoval K-17 .alpha.-Phthalimidoglutarimide THALIDOMIDE 2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione N-Phthalylglutamic acid imide N-(2,6-Dioxo-3-piperidyl)phthalimide Phthalimide, N-(2, 6-dioxo-3-piperidyl)-, (+)- N-Phthalylglutamic Acid Imide (+)-Thalidomide 3-Phthalimidoglutarimide N-Phthaloylglutamimide 2, 6-Dioxo-3-phthalimidopiperidine 2,6-Dioxo-3-phthalimidopiperidine Phthalimide, N-(2, 6-dioxo-3-piperidyl)-, (-)- Contergan Distaval Kevadon Neurosedyn Pantosediv Sedalis Softenon Synovir Talimol Thalomid |
|
Has_Target | ||
Is_Value_For_GDC_Property | ||
label |
Thalidomide |
|
Legacy Concept Name |
Thalidomide |
|
Maps_To |
Thalidomide |
|
NCI_Drug_Dictionary_ID |
42332 |
|
NSC Number |
66847 |
|
PDQ_Closed_Trial_Search_ID |
42332 |
|
PDQ_Open_Trial_Search_ID |
42332 |
|
Preferred_Name |
Thalidomide |
|
prefixIRI |
Thesaurus:C870 |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
UMLS_CUI |
C0039736 |
|
subClassOf |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1742 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C574 |