National Cancer Institute Thesaurus

Last uploaded: August 27, 2019
Preferred Name

Tetracycline

Synonyms

tetracycline

TETRACYCLINE

TCN

4-(Dimethylamino)-1,4,4A,5,5A,6,11,12A-Octahydro-3,6,10,12,12A-Pentahydroxy-6-Methyl-1,11-Dioxo-2-Naphthacenecarboxamide

Tetracycline

Definitions

A broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens. In bacteria, tetracycline binds to the 30S ribosomal subunit, interferes with the binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C865

ALT_DEFINITION

A drug used to treat bacterial infections. It stops the growth of bacteria by keeping them from making proteins. Tetracycline also binds to new bone tissue and is being studied as a way to detect bone growth. Tetracycline is a type of antibiotic and a type of bone-labeling agent.

CAS_Registry

60-54-8

CHEBI_ID

CHEBI:27902

Chemical_Formula

C22H24N2O8

code

C865

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens. In bacteria, tetracycline binds to the 30S ribosomal subunit, interferes with the binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis.

FDA_UNII_Code

F8VB5M810T

FULL_SYN

tetracycline

TETRACYCLINE

TCN

4-(Dimethylamino)-1,4,4A,5,5A,6,11,12A-Octahydro-3,6,10,12,12A-Pentahydroxy-6-Methyl-1,11-Dioxo-2-Naphthacenecarboxamide

Tetracycline

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98029

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48020

label

Tetracycline

Legacy_Concept_Name

Tetracycline

NSC_Code

108579

Preferred_Name

Tetracycline

prefixIRI

ncit:C865

Semantic_Type

Organic Chemical

Antibiotic

UMLS_CUI

C0039644

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1595

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http://www.projecthalo.com/aura#Tetracycline AURA LOOM
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