National Cancer Institute Thesaurus

Last uploaded: November 25, 2019
Preferred Name

Tamoxifen Citrate

Synonyms

Novofen

Ledertam

Fentamox

(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate

Apo-Tamox

Estroxyn

Oestrifen

Gen-Tamoxifen

Tamifen

ICI-46474

1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene Citrate

Nourytam

Novo-Tamoxifen

Soltamox

Zemide

Ebefen

Jenoxifen

Tamax

Noltam

Tamofen

Tamoxifen Citrate

TAM

TAMOXIFEN CITRATE

(Z)-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate

Emblon

Clonoxifen

Oncotam

ICI 46,474

PMS-Tamoxifen

Nolvadex-D

Tamoxasta

Nolvadex

Noxitem

Tamaxin

tamoxifen citrate

Genox

Lesporene

Tamizam

Dignotamoxi

Nolgen

Kessar

Tamoxifeni Citras

Tamoxifen citrate

Definitions

The citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. Tamoxifen also down-regulates protein kinase C (PKC) expression in a dose-dependant manner, inhibiting signal transduction and producing an antiproliferative effect in tumors such as malignant glioma and other cancers that overexpress PKC.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C855

Accepted_Therapeutic_Use_For

Breast cancer; Endometrial cancer; Gynecomastia; Melanoma; Ovarian cancer

ALT_DEFINITION

A drug used to treat certain types of breast cancer in women and men. It is also used to prevent breast cancer in women who have had ductal carcinoma in situ (abnormal cells in the ducts of the breast) and in women who are at a high risk of developing breast cancer. Tamoxifen citrate is also being studied in the treatment of other types of cancer. It blocks the effects of the hormone estrogen in the breast. Tamoxifen citrate is a type of antiestrogen.

CAS_Registry

54965-24-1

CHEBI_ID

CHEBI:9397

Chemical_Formula

C26H29NO.C6H8O7

code

C855

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

The citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. Tamoxifen also down-regulates protein kinase C (PKC) expression in a dose-dependant manner, inhibiting signal transduction and producing an antiproliferative effect in tumors such as malignant glioma and other cancers that overexpress PKC.

Display_Name

Tamoxifen Citrate

FDA_UNII_Code

7FRV7310N6

FULL_SYN

Novofen

Ledertam

Fentamox

(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate

Apo-Tamox

Estroxyn

Oestrifen

Gen-Tamoxifen

Tamifen

ICI-46474

1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene Citrate

Nourytam

Novo-Tamoxifen

Soltamox

Zemide

Ebefen

Jenoxifen

Tamax

Noltam

Tamofen

Tamoxifen Citrate

TAM

TAMOXIFEN CITRATE

(Z)-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate

Emblon

Clonoxifen

Oncotam

ICI 46,474

PMS-Tamoxifen

Nolvadex-D

Tamoxasta

Nolvadex

Noxitem

Tamaxin

tamoxifen citrate

Genox

Lesporene

Tamizam

Dignotamoxi

Nolgen

Kessar

Tamoxifeni Citras

Tamoxifen citrate

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62078

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38361

label

Tamoxifen Citrate

Legacy_Concept_Name

Tamoxifen

NSC_Code

180973

PDQ_Closed_Trial_Search_ID

42901

PDQ_Open_Trial_Search_ID

42901

Preferred_Name

Tamoxifen Citrate

prefixIRI

ncit:C855

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0700621

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1821

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2089

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