National Cancer Institute Thesaurus

Last uploaded: November 25, 2019
Preferred Name

Spironolactone

Synonyms

Aldactone

17-Hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic Acid, gamma Lactone, Acetate

SC 9420

Spironolactone

SPIRONOLACTONE

SPL

Definitions

A synthetic 17-spironolactone corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities.Spironolactone competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C840

CAS_Registry

52-01-7

CHEBI_ID

CHEBI:9241

Chemical_Formula

C24H32O4S

code

C840

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A synthetic 17-spironolactone corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities.Spironolactone competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors.

Display_Name

Spironolactone

FDA_UNII_Code

27O7W4T232

FULL_SYN

Aldactone

17-Hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic Acid, gamma Lactone, Acetate

SC 9420

Spironolactone

SPIRONOLACTONE

SPL

label

Spironolactone

Legacy_Concept_Name

Spironolactone

NSC_Code

150399

PDQ_Closed_Trial_Search_ID

39444

PDQ_Open_Trial_Search_ID

39444

Preferred_Name

Spironolactone

prefixIRI

ncit:C840

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0037982

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49186

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http://purl.bioontology.org/ontology/RCD/b43.. RCD LOOM
http://purl.bioontology.org/ontology/SNMI/C-72420 SNMI LOOM
http://purl.jp/bio/4/id/200906028579154843 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/LP16280-7 LOINC LOOM
http://purl.bioontology.org/ontology/CSP/2794-2536 CRISP LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.745.745.855 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D013148 MESH LOOM
https://bioportal.bioontology.org/ontologies/FTDM.owl#spironolactone FASTO LOOM
http://www.ifomis.org/acgt/1.0#Spironolactone ACGT-MO LOOM
http://purl.bioontology.org/ontology/UATC/C03DA01 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.540.679 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003227 LOINC LOOM
http://www.drugbank.ca/drugs/DB00421 FTC LOOM
http://purl.bioontology.org/ontology/VANDF/4017881 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146234 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D013148 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_9241 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_9241 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9241 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_9241 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9241 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_9241 NIFSTD LOOM
http://purl.obolibrary.org/obo/XCO_0000627 XCO LOOM
http://purl.obolibrary.org/obo/XCO_0000627 XCO LOOM
http://www.co-ode.org/ontologies/galen#Spironolactone GALEN LOOM
http://purl.bioontology.org/ontology/RXNORM/9997 RXNORM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387078006 SNOMEDCT LOOM
http://bmi.utah.edu/ontologies/hfontology/C0037982 HFO LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039444 PDQ LOOM
http://stirdf.jst.go.jp/id/200907023665510166 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0037982 OCHV LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#11637 OCHV LOOM